Robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion

The brain is a genomic mosaic shaped by somatic mutations and cellular responses that correct or purge these mutations. Here, by manipulating genome stability during embryonic brain development, authors revealed robust mechanisms that eliminate cells with genome damage from the brain, and the conseq...

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Autores principales:	Lei Shi, Adel Qalieh, Mandy M. Lam, Jason M. Keil, Kenneth Y. Kwan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fc3234fbb7164890a3113aeffc7bddda
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spelling	oai:doaj.org-article:fc3234fbb7164890a3113aeffc7bddda2021-12-02T15:36:19ZRobust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion10.1038/s41467-019-10411-w2041-1723https://doaj.org/article/fc3234fbb7164890a3113aeffc7bddda2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10411-whttps://doaj.org/toc/2041-1723The brain is a genomic mosaic shaped by somatic mutations and cellular responses that correct or purge these mutations. Here, by manipulating genome stability during embryonic brain development, authors revealed robust mechanisms that eliminate cells with genome damage from the brain, and the consequences of leaving somatic mutants unpurgedLei ShiAdel QaliehMandy M. LamJason M. KeilKenneth Y. KwanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lei Shi Adel Qalieh Mandy M. Lam Jason M. Keil Kenneth Y. Kwan Robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion
description	The brain is a genomic mosaic shaped by somatic mutations and cellular responses that correct or purge these mutations. Here, by manipulating genome stability during embryonic brain development, authors revealed robust mechanisms that eliminate cells with genome damage from the brain, and the consequences of leaving somatic mutants unpurged
format	article
author	Lei Shi Adel Qalieh Mandy M. Lam Jason M. Keil Kenneth Y. Kwan
author_facet	Lei Shi Adel Qalieh Mandy M. Lam Jason M. Keil Kenneth Y. Kwan
author_sort	Lei Shi
title	Robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion
title_short	Robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion
title_full	Robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion
title_fullStr	Robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion
title_full_unstemmed	Robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion
title_sort	robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following knl1 deletion
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/fc3234fbb7164890a3113aeffc7bddda
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Robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion

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