Beta-Casein Gene Polymorphism in Serbian Holstein-Friesian Cows and Its Relationship with Milk Production Traits

The most common types of beta-casein in cow’s milk are A1 and A2, which differ in one amino acid. During the gastrointestinal proteolysis of A1 beta-casein in humans this difference results in the release of beta-casomorphin-7, an opioid which may lead to severe effects on human health, causing vari...

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Autores principales:	Marko Ristanic, Uros Glavinic, Branislav Vejnovic, Milan Maletic, Danijela Kirovski, Vlado Teodorovic, Zoran Stanimirovic
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2020
Materias:	holstein-friesian beta-casein allele frequency genotype frequency rflp-pcr milk productivity traits Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/fc45b404117b45cfa28dee9eec7e73cc
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spelling	oai:doaj.org-article:fc45b404117b45cfa28dee9eec7e73cc2021-11-17T21:27:54ZBeta-Casein Gene Polymorphism in Serbian Holstein-Friesian Cows and Its Relationship with Milk Production Traits1820-744810.2478/acve-2020-0037https://doaj.org/article/fc45b404117b45cfa28dee9eec7e73cc2020-12-01T00:00:00Zhttps://doi.org/10.2478/acve-2020-0037https://doaj.org/toc/1820-7448The most common types of beta-casein in cow’s milk are A1 and A2, which differ in one amino acid. During the gastrointestinal proteolysis of A1 beta-casein in humans this difference results in the release of beta-casomorphin-7, an opioid which may lead to severe effects on human health, causing various ailments (type-1 diabetes mellitus, ischemic heart disease, arteriosclerosis, sudden infant death syndrome, autism, schizophrenia, gastrointestinal digestive discomfort, as well as increased gastrointestinal transit time). By contrast, A2 beta-casein cannot exert these effects owing to its different composition and metabolism. Furthermore, studies have shown that it can influence milk productivity traits. Our research aimed to screen the frequency of A1 and A2 alleles of beta-casein gene in a population of Serbian Holstein-Friesian cows and to detect how the genotypes influence milk production, and milk protein and fat yields. Out of 106 animals, 13 (12.26%) were of A1A1 genotype, 58 (54.72%) of A1A2, and 35 (33.02%) of A2A2 genotype. Milk yield was significantly (P<0.01) higher in A2A2 compared to both A1A1 and A1A2 genotypes. Milk protein concentrations were significantly (P<0.01) higher in A2A2 compared to A1A2 genotype, while milk fat concentrations were significantly (P<0.01) higher in A2A2 compared to both A1A1 and A1A2 genotypes.Marko RistanicUros GlavinicBranislav VejnovicMilan MaleticDanijela KirovskiVlado TeodorovicZoran StanimirovicSciendoarticleholstein-friesianbeta-caseinallele frequencygenotype frequencyrflp-pcrmilk productivity traitsVeterinary medicineSF600-1100ENActa Veterinaria, Vol 70, Iss 4, Pp 497-510 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	holstein-friesian beta-casein allele frequency genotype frequency rflp-pcr milk productivity traits Veterinary medicine SF600-1100
spellingShingle	holstein-friesian beta-casein allele frequency genotype frequency rflp-pcr milk productivity traits Veterinary medicine SF600-1100 Marko Ristanic Uros Glavinic Branislav Vejnovic Milan Maletic Danijela Kirovski Vlado Teodorovic Zoran Stanimirovic Beta-Casein Gene Polymorphism in Serbian Holstein-Friesian Cows and Its Relationship with Milk Production Traits
description	The most common types of beta-casein in cow’s milk are A1 and A2, which differ in one amino acid. During the gastrointestinal proteolysis of A1 beta-casein in humans this difference results in the release of beta-casomorphin-7, an opioid which may lead to severe effects on human health, causing various ailments (type-1 diabetes mellitus, ischemic heart disease, arteriosclerosis, sudden infant death syndrome, autism, schizophrenia, gastrointestinal digestive discomfort, as well as increased gastrointestinal transit time). By contrast, A2 beta-casein cannot exert these effects owing to its different composition and metabolism. Furthermore, studies have shown that it can influence milk productivity traits. Our research aimed to screen the frequency of A1 and A2 alleles of beta-casein gene in a population of Serbian Holstein-Friesian cows and to detect how the genotypes influence milk production, and milk protein and fat yields. Out of 106 animals, 13 (12.26%) were of A1A1 genotype, 58 (54.72%) of A1A2, and 35 (33.02%) of A2A2 genotype. Milk yield was significantly (P<0.01) higher in A2A2 compared to both A1A1 and A1A2 genotypes. Milk protein concentrations were significantly (P<0.01) higher in A2A2 compared to A1A2 genotype, while milk fat concentrations were significantly (P<0.01) higher in A2A2 compared to both A1A1 and A1A2 genotypes.
format	article
author	Marko Ristanic Uros Glavinic Branislav Vejnovic Milan Maletic Danijela Kirovski Vlado Teodorovic Zoran Stanimirovic
author_facet	Marko Ristanic Uros Glavinic Branislav Vejnovic Milan Maletic Danijela Kirovski Vlado Teodorovic Zoran Stanimirovic
author_sort	Marko Ristanic
title	Beta-Casein Gene Polymorphism in Serbian Holstein-Friesian Cows and Its Relationship with Milk Production Traits
title_short	Beta-Casein Gene Polymorphism in Serbian Holstein-Friesian Cows and Its Relationship with Milk Production Traits
title_full	Beta-Casein Gene Polymorphism in Serbian Holstein-Friesian Cows and Its Relationship with Milk Production Traits
title_fullStr	Beta-Casein Gene Polymorphism in Serbian Holstein-Friesian Cows and Its Relationship with Milk Production Traits
title_full_unstemmed	Beta-Casein Gene Polymorphism in Serbian Holstein-Friesian Cows and Its Relationship with Milk Production Traits
title_sort	beta-casein gene polymorphism in serbian holstein-friesian cows and its relationship with milk production traits
publisher	Sciendo
publishDate	2020
url	https://doaj.org/article/fc45b404117b45cfa28dee9eec7e73cc
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Beta-Casein Gene Polymorphism in Serbian Holstein-Friesian Cows and Its Relationship with Milk Production Traits

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