Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform

In vitro models of the human mammary gland have struggled to mimic the 3D morphogenic processes that occur in vivo. Here the authors develop a 3D microfluidic platform of a vascularized human mammary duct that simulates diverse morphogenic transitions and paracrine crosstalk.

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Autores principales: Matthew L. Kutys, William J. Polacheck, Michaela K. Welch, Keith A. Gagnon, Thijs Koorman, Sudong Kim, Linqing Li, Andrea I. McClatchey, Christopher S. Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/fc47e360b48b4cc09a44155a0d644ab7
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