Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform

In vitro models of the human mammary gland have struggled to mimic the 3D morphogenic processes that occur in vivo. Here the authors develop a 3D microfluidic platform of a vascularized human mammary duct that simulates diverse morphogenic transitions and paracrine crosstalk.

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Autores principales:	Matthew L. Kutys, William J. Polacheck, Michaela K. Welch, Keith A. Gagnon, Thijs Koorman, Sudong Kim, Linqing Li, Andrea I. McClatchey, Christopher S. Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fc47e360b48b4cc09a44155a0d644ab7
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spelling	oai:doaj.org-article:fc47e360b48b4cc09a44155a0d644ab72021-12-02T18:34:22ZUncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform10.1038/s41467-020-17102-x2041-1723https://doaj.org/article/fc47e360b48b4cc09a44155a0d644ab72020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17102-xhttps://doaj.org/toc/2041-1723In vitro models of the human mammary gland have struggled to mimic the 3D morphogenic processes that occur in vivo. Here the authors develop a 3D microfluidic platform of a vascularized human mammary duct that simulates diverse morphogenic transitions and paracrine crosstalk.Matthew L. KutysWilliam J. PolacheckMichaela K. WelchKeith A. GagnonThijs KoormanSudong KimLinqing LiAndrea I. McClatcheyChristopher S. ChenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthew L. Kutys William J. Polacheck Michaela K. Welch Keith A. Gagnon Thijs Koorman Sudong Kim Linqing Li Andrea I. McClatchey Christopher S. Chen Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform
description	In vitro models of the human mammary gland have struggled to mimic the 3D morphogenic processes that occur in vivo. Here the authors develop a 3D microfluidic platform of a vascularized human mammary duct that simulates diverse morphogenic transitions and paracrine crosstalk.
format	article
author	Matthew L. Kutys William J. Polacheck Michaela K. Welch Keith A. Gagnon Thijs Koorman Sudong Kim Linqing Li Andrea I. McClatchey Christopher S. Chen
author_facet	Matthew L. Kutys William J. Polacheck Michaela K. Welch Keith A. Gagnon Thijs Koorman Sudong Kim Linqing Li Andrea I. McClatchey Christopher S. Chen
author_sort	Matthew L. Kutys
title	Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform
title_short	Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform
title_full	Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform
title_fullStr	Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform
title_full_unstemmed	Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform
title_sort	uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fc47e360b48b4cc09a44155a0d644ab7
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Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform

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