A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells

In fast proliferating embryonic stem cells (ESC) the DNA damage response is activated by mechanisms that are as yet elusive. Here, Ahuja et al.link the DNA damage response to replication stress in mouse ESCs, caused by a short G1 phase, and propose fork remodelling as maintaining genome stability in...

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Autores principales: Akshay K. Ahuja, Karolina Jodkowska, Federico Teloni, Anna H. Bizard, Ralph Zellweger, Raquel Herrador, Sagrario Ortega, Ian D. Hickson, Matthias Altmeyer, Juan Mendez, Massimo Lopes
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/fc4914771f1340c399684df4e94a8bca
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