A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells

In fast proliferating embryonic stem cells (ESC) the DNA damage response is activated by mechanisms that are as yet elusive. Here, Ahuja et al.link the DNA damage response to replication stress in mouse ESCs, caused by a short G1 phase, and propose fork remodelling as maintaining genome stability in...

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Autores principales:	Akshay K. Ahuja, Karolina Jodkowska, Federico Teloni, Anna H. Bizard, Ralph Zellweger, Raquel Herrador, Sagrario Ortega, Ian D. Hickson, Matthias Altmeyer, Juan Mendez, Massimo Lopes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fc4914771f1340c399684df4e94a8bca
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spelling	oai:doaj.org-article:fc4914771f1340c399684df4e94a8bca2021-12-02T14:39:14ZA short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells10.1038/ncomms106602041-1723https://doaj.org/article/fc4914771f1340c399684df4e94a8bca2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10660https://doaj.org/toc/2041-1723In fast proliferating embryonic stem cells (ESC) the DNA damage response is activated by mechanisms that are as yet elusive. Here, Ahuja et al.link the DNA damage response to replication stress in mouse ESCs, caused by a short G1 phase, and propose fork remodelling as maintaining genome stability in embryos.Akshay K. AhujaKarolina JodkowskaFederico TeloniAnna H. BizardRalph ZellwegerRaquel HerradorSagrario OrtegaIan D. HicksonMatthias AltmeyerJuan MendezMassimo LopesNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Akshay K. Ahuja Karolina Jodkowska Federico Teloni Anna H. Bizard Ralph Zellweger Raquel Herrador Sagrario Ortega Ian D. Hickson Matthias Altmeyer Juan Mendez Massimo Lopes A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells
description	In fast proliferating embryonic stem cells (ESC) the DNA damage response is activated by mechanisms that are as yet elusive. Here, Ahuja et al.link the DNA damage response to replication stress in mouse ESCs, caused by a short G1 phase, and propose fork remodelling as maintaining genome stability in embryos.
format	article
author	Akshay K. Ahuja Karolina Jodkowska Federico Teloni Anna H. Bizard Ralph Zellweger Raquel Herrador Sagrario Ortega Ian D. Hickson Matthias Altmeyer Juan Mendez Massimo Lopes
author_facet	Akshay K. Ahuja Karolina Jodkowska Federico Teloni Anna H. Bizard Ralph Zellweger Raquel Herrador Sagrario Ortega Ian D. Hickson Matthias Altmeyer Juan Mendez Massimo Lopes
author_sort	Akshay K. Ahuja
title	A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells
title_short	A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells
title_full	A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells
title_fullStr	A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells
title_full_unstemmed	A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells
title_sort	short g1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/fc4914771f1340c399684df4e94a8bca
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A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells

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