Screening of anti-allergy Lactobacillus and its effect on allergic reactions in BALB/c mice sensitized by soybean protein

Lactobacillus has been widely used in food due to its various beneficial functions and its effects on food allergies have also been reported. This study aimed to investigate the role of Lactobacillus in alleviating soybean allergy. Three strains with potential intervention in soybean allergy were sc...

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Autores principales:	Anshu Yang, Yaru Liao, Jierui Zhu, Jie Zhang, Zhihua Wu, Xin Li, Ping Tong, Hongbing Chen, Shuixing Wang, Zhiyong Liu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Lactobacillus Soybean allergy Intervention Immunomodulation BALB/c mice Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/fc57ee604edf4ed7a155a3cf36c6ef42
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spelling	oai:doaj.org-article:fc57ee604edf4ed7a155a3cf36c6ef422021-11-20T04:57:35ZScreening of anti-allergy Lactobacillus and its effect on allergic reactions in BALB/c mice sensitized by soybean protein1756-464610.1016/j.jff.2021.104858https://doaj.org/article/fc57ee604edf4ed7a155a3cf36c6ef422021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1756464621005077https://doaj.org/toc/1756-4646Lactobacillus has been widely used in food due to its various beneficial functions and its effects on food allergies have also been reported. This study aimed to investigate the role of Lactobacillus in alleviating soybean allergy. Three strains with potential intervention in soybean allergy were screened by co-culture with mouse splenocytes in vitro. The BALB/c mice model of soybean sensitization was established to evaluate their anti-allergy effect. The results showed that the three selected strains alleviated the allergic symptoms of sensitized mice, reduced the levels of IgE, IgG, and IgG1 in serum, up-regulated the levels of interleukin (IL)-2, interferon-γ, and IL-10, and down-regulated the levels of IL-4, IL-6, and IL-17A. In addition, the three strains suppressed the expression of mast cells and promoted the proportion of regulatory T cells (Tregs). Thus, the three strains of Lactobacillus have potential as dietary supplements for the treatment of soybean allergy.Anshu YangYaru LiaoJierui ZhuJie ZhangZhihua WuXin LiPing TongHongbing ChenShuixing WangZhiyong LiuElsevierarticleLactobacillusSoybean allergyInterventionImmunomodulationBALB/c miceNutrition. Foods and food supplyTX341-641ENJournal of Functional Foods, Vol 87, Iss , Pp 104858- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Lactobacillus Soybean allergy Intervention Immunomodulation BALB/c mice Nutrition. Foods and food supply TX341-641
spellingShingle	Lactobacillus Soybean allergy Intervention Immunomodulation BALB/c mice Nutrition. Foods and food supply TX341-641 Anshu Yang Yaru Liao Jierui Zhu Jie Zhang Zhihua Wu Xin Li Ping Tong Hongbing Chen Shuixing Wang Zhiyong Liu Screening of anti-allergy Lactobacillus and its effect on allergic reactions in BALB/c mice sensitized by soybean protein
description	Lactobacillus has been widely used in food due to its various beneficial functions and its effects on food allergies have also been reported. This study aimed to investigate the role of Lactobacillus in alleviating soybean allergy. Three strains with potential intervention in soybean allergy were screened by co-culture with mouse splenocytes in vitro. The BALB/c mice model of soybean sensitization was established to evaluate their anti-allergy effect. The results showed that the three selected strains alleviated the allergic symptoms of sensitized mice, reduced the levels of IgE, IgG, and IgG1 in serum, up-regulated the levels of interleukin (IL)-2, interferon-γ, and IL-10, and down-regulated the levels of IL-4, IL-6, and IL-17A. In addition, the three strains suppressed the expression of mast cells and promoted the proportion of regulatory T cells (Tregs). Thus, the three strains of Lactobacillus have potential as dietary supplements for the treatment of soybean allergy.
format	article
author	Anshu Yang Yaru Liao Jierui Zhu Jie Zhang Zhihua Wu Xin Li Ping Tong Hongbing Chen Shuixing Wang Zhiyong Liu
author_facet	Anshu Yang Yaru Liao Jierui Zhu Jie Zhang Zhihua Wu Xin Li Ping Tong Hongbing Chen Shuixing Wang Zhiyong Liu
author_sort	Anshu Yang
title	Screening of anti-allergy Lactobacillus and its effect on allergic reactions in BALB/c mice sensitized by soybean protein
title_short	Screening of anti-allergy Lactobacillus and its effect on allergic reactions in BALB/c mice sensitized by soybean protein
title_full	Screening of anti-allergy Lactobacillus and its effect on allergic reactions in BALB/c mice sensitized by soybean protein
title_fullStr	Screening of anti-allergy Lactobacillus and its effect on allergic reactions in BALB/c mice sensitized by soybean protein
title_full_unstemmed	Screening of anti-allergy Lactobacillus and its effect on allergic reactions in BALB/c mice sensitized by soybean protein
title_sort	screening of anti-allergy lactobacillus and its effect on allergic reactions in balb/c mice sensitized by soybean protein
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/fc57ee604edf4ed7a155a3cf36c6ef42
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Screening of anti-allergy Lactobacillus and its effect on allergic reactions in BALB/c mice sensitized by soybean protein

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