The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation

Thioredoxin (Trx), Trx reductase, Txnip and NADPH together comprise the Trx system. Here the authors make a T cell-specific thioredoxin reductase-1 knockout mouse to show how this system reprograms cellular metabolism to enable T cell development, proliferation and responses.

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Autores principales:	Jonathan Muri, Sebastian Heer, Mai Matsushita, Lea Pohlmeier, Luigi Tortola, Tobias Fuhrer, Marcus Conrad, Nicola Zamboni, Jan Kisielow, Manfred Kopf
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fcad0513f85e4a638f4a7ad39f2c3972
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spelling	oai:doaj.org-article:fcad0513f85e4a638f4a7ad39f2c39722021-12-02T15:34:24ZThe thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation10.1038/s41467-018-04274-w2041-1723https://doaj.org/article/fcad0513f85e4a638f4a7ad39f2c39722018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04274-whttps://doaj.org/toc/2041-1723Thioredoxin (Trx), Trx reductase, Txnip and NADPH together comprise the Trx system. Here the authors make a T cell-specific thioredoxin reductase-1 knockout mouse to show how this system reprograms cellular metabolism to enable T cell development, proliferation and responses.Jonathan MuriSebastian HeerMai MatsushitaLea PohlmeierLuigi TortolaTobias FuhrerMarcus ConradNicola ZamboniJan KisielowManfred KopfNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jonathan Muri Sebastian Heer Mai Matsushita Lea Pohlmeier Luigi Tortola Tobias Fuhrer Marcus Conrad Nicola Zamboni Jan Kisielow Manfred Kopf The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation
description	Thioredoxin (Trx), Trx reductase, Txnip and NADPH together comprise the Trx system. Here the authors make a T cell-specific thioredoxin reductase-1 knockout mouse to show how this system reprograms cellular metabolism to enable T cell development, proliferation and responses.
format	article
author	Jonathan Muri Sebastian Heer Mai Matsushita Lea Pohlmeier Luigi Tortola Tobias Fuhrer Marcus Conrad Nicola Zamboni Jan Kisielow Manfred Kopf
author_facet	Jonathan Muri Sebastian Heer Mai Matsushita Lea Pohlmeier Luigi Tortola Tobias Fuhrer Marcus Conrad Nicola Zamboni Jan Kisielow Manfred Kopf
author_sort	Jonathan Muri
title	The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation
title_short	The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation
title_full	The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation
title_fullStr	The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation
title_full_unstemmed	The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation
title_sort	thioredoxin-1 system is essential for fueling dna synthesis during t-cell metabolic reprogramming and proliferation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fcad0513f85e4a638f4a7ad39f2c3972
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The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation

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