Rational design of a hypoallergenic Phl p 7 variant for immunotherapy of polcalcin-sensitized patients

Rational design of a hypoallergenic Phl p 7 variant for immunotherapy of polcalcin-sensitized patients

Abstract Polcalcins are important respiratory panallergens, whose IgE-binding capacity depends on the presence of calcium. Since specific immunotherapy is not yet available for the treatment of polcalcin-sensitized patients, we aimed to develop a molecule for efficient and safe immunotherapy. We gen...

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Autores principales: Marianne Raith, Doris Zach, Linda Sonnleitner, Konrad Woroszylo, Margarete Focke-Tejkl, Herbert Wank, Thorsten Graf, Annette Kuehn, Mariona Pascal, Rosa Maria Muñoz-Cano, Judith Wortmann, Philipp Aschauer, Walter Keller, Simone Braeuer, Walter Goessler, Ines Swoboda
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/fcb00871019f4927a66904b86062fd11
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https://doaj.org/article/fcb00871019f4927a66904b86062fd11

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