Antibiotic collateral sensitivity is contingent on the repeatability of evolution

The evolution of resistance to an antibiotic can render bacteria more susceptible, or more resistant, to a second antibiotic. Here, Nichol et al. provide evidence that the final outcome can be fairly stochastic and depends on the shape of the evolutionary fitness landscape.

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Autores principales:	Daniel Nichol, Joseph Rutter, Christopher Bryant, Andrea M. Hujer, Sai Lek, Mark D. Adams, Peter Jeavons, Alexander R. A. Anderson, Robert A. Bonomo, Jacob G. Scott
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fcd27466c5b448a4a8dd0543dc7be5c4
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spelling	oai:doaj.org-article:fcd27466c5b448a4a8dd0543dc7be5c42021-12-02T16:50:57ZAntibiotic collateral sensitivity is contingent on the repeatability of evolution10.1038/s41467-018-08098-62041-1723https://doaj.org/article/fcd27466c5b448a4a8dd0543dc7be5c42019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08098-6https://doaj.org/toc/2041-1723The evolution of resistance to an antibiotic can render bacteria more susceptible, or more resistant, to a second antibiotic. Here, Nichol et al. provide evidence that the final outcome can be fairly stochastic and depends on the shape of the evolutionary fitness landscape.Daniel NicholJoseph RutterChristopher BryantAndrea M. HujerSai LekMark D. AdamsPeter JeavonsAlexander R. A. AndersonRobert A. BonomoJacob G. ScottNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel Nichol Joseph Rutter Christopher Bryant Andrea M. Hujer Sai Lek Mark D. Adams Peter Jeavons Alexander R. A. Anderson Robert A. Bonomo Jacob G. Scott Antibiotic collateral sensitivity is contingent on the repeatability of evolution
description	The evolution of resistance to an antibiotic can render bacteria more susceptible, or more resistant, to a second antibiotic. Here, Nichol et al. provide evidence that the final outcome can be fairly stochastic and depends on the shape of the evolutionary fitness landscape.
format	article
author	Daniel Nichol Joseph Rutter Christopher Bryant Andrea M. Hujer Sai Lek Mark D. Adams Peter Jeavons Alexander R. A. Anderson Robert A. Bonomo Jacob G. Scott
author_facet	Daniel Nichol Joseph Rutter Christopher Bryant Andrea M. Hujer Sai Lek Mark D. Adams Peter Jeavons Alexander R. A. Anderson Robert A. Bonomo Jacob G. Scott
author_sort	Daniel Nichol
title	Antibiotic collateral sensitivity is contingent on the repeatability of evolution
title_short	Antibiotic collateral sensitivity is contingent on the repeatability of evolution
title_full	Antibiotic collateral sensitivity is contingent on the repeatability of evolution
title_fullStr	Antibiotic collateral sensitivity is contingent on the repeatability of evolution
title_full_unstemmed	Antibiotic collateral sensitivity is contingent on the repeatability of evolution
title_sort	antibiotic collateral sensitivity is contingent on the repeatability of evolution
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/fcd27466c5b448a4a8dd0543dc7be5c4
work_keys_str_mv	AT danielnichol antibioticcollateralsensitivityiscontingentontherepeatabilityofevolution AT josephrutter antibioticcollateralsensitivityiscontingentontherepeatabilityofevolution AT christopherbryant antibioticcollateralsensitivityiscontingentontherepeatabilityofevolution AT andreamhujer antibioticcollateralsensitivityiscontingentontherepeatabilityofevolution AT sailek antibioticcollateralsensitivityiscontingentontherepeatabilityofevolution AT markdadams antibioticcollateralsensitivityiscontingentontherepeatabilityofevolution AT peterjeavons antibioticcollateralsensitivityiscontingentontherepeatabilityofevolution AT alexanderraanderson antibioticcollateralsensitivityiscontingentontherepeatabilityofevolution AT robertabonomo antibioticcollateralsensitivityiscontingentontherepeatabilityofevolution AT jacobgscott antibioticcollateralsensitivityiscontingentontherepeatabilityofevolution
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Antibiotic collateral sensitivity is contingent on the repeatability of evolution

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