Symmetrically dimethylated histone H3R2 promotes global transcription during minor zygotic genome activation in mouse pronuclei

Abstract Paternal genome reprogramming, such as protamine–histone exchange and global DNA demethylation, is crucial for the development of fertilised embryos. Previously, our study showed that one of histone arginine methylation, asymmetrically dimethylated histone H3R17 (H3R17me2a), is necessary fo...

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Autores principales: Kohtaro Morita, Yuki Hatanaka, Shunya Ihashi, Masahide Asano, Kei Miyamoto, Kazuya Matsumoto
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/fcf3c10f47fa40f084b91b050f1310a6
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