Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation

Lymphatic malformation (LM) is a debilitating often incurable vascular disease. Using a mouse model of LM driven by a disease-causative PIK3CA mutation, the authors show that vascular growth is dependent on the upstream lymphangiogenic VEGF-C signalling, permitting effective therapeutic intervention...

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Autores principales:	Ines Martinez-Corral, Yan Zhang, Milena Petkova, Henrik Ortsäter, Sofie Sjöberg, Sandra D. Castillo, Pascal Brouillard, Louis Libbrecht, Dieter Saur, Mariona Graupera, Kari Alitalo, Laurence Boon, Miikka Vikkula, Taija Mäkinen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fd1266859f49458da77848ac93b05ccf
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spelling	oai:doaj.org-article:fd1266859f49458da77848ac93b05ccf2021-12-02T17:47:17ZBlockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation10.1038/s41467-020-16496-y2041-1723https://doaj.org/article/fd1266859f49458da77848ac93b05ccf2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16496-yhttps://doaj.org/toc/2041-1723Lymphatic malformation (LM) is a debilitating often incurable vascular disease. Using a mouse model of LM driven by a disease-causative PIK3CA mutation, the authors show that vascular growth is dependent on the upstream lymphangiogenic VEGF-C signalling, permitting effective therapeutic intervention.Ines Martinez-CorralYan ZhangMilena PetkovaHenrik OrtsäterSofie SjöbergSandra D. CastilloPascal BrouillardLouis LibbrechtDieter SaurMariona GrauperaKari AlitaloLaurence BoonMiikka VikkulaTaija MäkinenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ines Martinez-Corral Yan Zhang Milena Petkova Henrik Ortsäter Sofie Sjöberg Sandra D. Castillo Pascal Brouillard Louis Libbrecht Dieter Saur Mariona Graupera Kari Alitalo Laurence Boon Miikka Vikkula Taija Mäkinen Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation
description	Lymphatic malformation (LM) is a debilitating often incurable vascular disease. Using a mouse model of LM driven by a disease-causative PIK3CA mutation, the authors show that vascular growth is dependent on the upstream lymphangiogenic VEGF-C signalling, permitting effective therapeutic intervention.
format	article
author	Ines Martinez-Corral Yan Zhang Milena Petkova Henrik Ortsäter Sofie Sjöberg Sandra D. Castillo Pascal Brouillard Louis Libbrecht Dieter Saur Mariona Graupera Kari Alitalo Laurence Boon Miikka Vikkula Taija Mäkinen
author_facet	Ines Martinez-Corral Yan Zhang Milena Petkova Henrik Ortsäter Sofie Sjöberg Sandra D. Castillo Pascal Brouillard Louis Libbrecht Dieter Saur Mariona Graupera Kari Alitalo Laurence Boon Miikka Vikkula Taija Mäkinen
author_sort	Ines Martinez-Corral
title	Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation
title_short	Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation
title_full	Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation
title_fullStr	Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation
title_full_unstemmed	Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation
title_sort	blockade of vegf-c signaling inhibits lymphatic malformations driven by oncogenic pik3ca mutation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fd1266859f49458da77848ac93b05ccf
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Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation

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