Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm

Hedgehog (Hh) controls embryonic development via interaction with its receptor Patched (Ptch). Here the authors report the cryo-EM structure of tetrameric Ptch1 in complex with the palmitoylated N-terminal signaling domain of human Sonic hedgehog (ShhNp) at a 4:2 stoichiometric ratio.

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Detalles Bibliográficos
Autores principales: Hongwu Qian, Pingping Cao, Miaohui Hu, Shuai Gao, Nieng Yan, Xin Gong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/fd4815694c8c4fb7b4dd4c78bc0cfff4
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