Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm

Hedgehog (Hh) controls embryonic development via interaction with its receptor Patched (Ptch). Here the authors report the cryo-EM structure of tetrameric Ptch1 in complex with the palmitoylated N-terminal signaling domain of human Sonic hedgehog (ShhNp) at a 4:2 stoichiometric ratio.

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Autores principales:	Hongwu Qian, Pingping Cao, Miaohui Hu, Shuai Gao, Nieng Yan, Xin Gong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fd4815694c8c4fb7b4dd4c78bc0cfff4
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spelling	oai:doaj.org-article:fd4815694c8c4fb7b4dd4c78bc0cfff42021-12-02T15:35:35ZInhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm10.1038/s41467-019-10234-92041-1723https://doaj.org/article/fd4815694c8c4fb7b4dd4c78bc0cfff42019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10234-9https://doaj.org/toc/2041-1723Hedgehog (Hh) controls embryonic development via interaction with its receptor Patched (Ptch). Here the authors report the cryo-EM structure of tetrameric Ptch1 in complex with the palmitoylated N-terminal signaling domain of human Sonic hedgehog (ShhNp) at a 4:2 stoichiometric ratio.Hongwu QianPingping CaoMiaohui HuShuai GaoNieng YanXin GongNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hongwu Qian Pingping Cao Miaohui Hu Shuai Gao Nieng Yan Xin Gong Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm
description	Hedgehog (Hh) controls embryonic development via interaction with its receptor Patched (Ptch). Here the authors report the cryo-EM structure of tetrameric Ptch1 in complex with the palmitoylated N-terminal signaling domain of human Sonic hedgehog (ShhNp) at a 4:2 stoichiometric ratio.
format	article
author	Hongwu Qian Pingping Cao Miaohui Hu Shuai Gao Nieng Yan Xin Gong
author_facet	Hongwu Qian Pingping Cao Miaohui Hu Shuai Gao Nieng Yan Xin Gong
author_sort	Hongwu Qian
title	Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm
title_short	Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm
title_full	Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm
title_fullStr	Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm
title_full_unstemmed	Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm
title_sort	inhibition of tetrameric patched1 by sonic hedgehog through an asymmetric paradigm
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/fd4815694c8c4fb7b4dd4c78bc0cfff4
work_keys_str_mv	AT hongwuqian inhibitionoftetramericpatched1bysonichedgehogthroughanasymmetricparadigm AT pingpingcao inhibitionoftetramericpatched1bysonichedgehogthroughanasymmetricparadigm AT miaohuihu inhibitionoftetramericpatched1bysonichedgehogthroughanasymmetricparadigm AT shuaigao inhibitionoftetramericpatched1bysonichedgehogthroughanasymmetricparadigm AT niengyan inhibitionoftetramericpatched1bysonichedgehogthroughanasymmetricparadigm AT xingong inhibitionoftetramericpatched1bysonichedgehogthroughanasymmetricparadigm
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Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm

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