Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm

Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm

Hedgehog (Hh) controls embryonic development via interaction with its receptor Patched (Ptch). Here the authors report the cryo-EM structure of tetrameric Ptch1 in complex with the palmitoylated N-terminal signaling domain of human Sonic hedgehog (ShhNp) at a 4:2 stoichiometric ratio.

Guardado en:
Detalles Bibliográficos
Autores principales: Hongwu Qian, Pingping Cao, Miaohui Hu, Shuai Gao, Nieng Yan, Xin Gong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/fd4815694c8c4fb7b4dd4c78bc0cfff4
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Ejemplares similares