Genomic landscape of platinum resistant and sensitive testicular cancers
Most testicular germ-cell tumours are exquisitely sensitive to platinum-based chemotherapies, but little is known about why 10% are resistant. Here, the authors explore the potential underlying mechanisms by probing the genomic landscape of platinum-resistant disease.
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Nature Portfolio
2020
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oai:doaj.org-article:fd830b167ba2414b9bc17a0f92cc02a52021-12-02T14:42:31ZGenomic landscape of platinum resistant and sensitive testicular cancers10.1038/s41467-020-15768-x2041-1723https://doaj.org/article/fd830b167ba2414b9bc17a0f92cc02a52020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15768-xhttps://doaj.org/toc/2041-1723Most testicular germ-cell tumours are exquisitely sensitive to platinum-based chemotherapies, but little is known about why 10% are resistant. Here, the authors explore the potential underlying mechanisms by probing the genomic landscape of platinum-resistant disease.Chey LovedayKevin LitchfieldPaula Z. ProszekAlex J. CornishFlavia SantoMax LevyGeoff MacintyreAmy HolryodPeter BroderickDarshna DudakiaBarbara BentonMaise Al BakirCrispin HileyEmily GristCharles SwantonRobert HuddartTom PowlesSimon ChowdhuryJanet ShipleySimon O’ConnorJames D. BrentonAlison ReidDavid Gonzalez de CastroRichard S. HoulstonClare TurnbullNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Chey Loveday Kevin Litchfield Paula Z. Proszek Alex J. Cornish Flavia Santo Max Levy Geoff Macintyre Amy Holryod Peter Broderick Darshna Dudakia Barbara Benton Maise Al Bakir Crispin Hiley Emily Grist Charles Swanton Robert Huddart Tom Powles Simon Chowdhury Janet Shipley Simon O’Connor James D. Brenton Alison Reid David Gonzalez de Castro Richard S. Houlston Clare Turnbull Genomic landscape of platinum resistant and sensitive testicular cancers |
| description |
Most testicular germ-cell tumours are exquisitely sensitive to platinum-based chemotherapies, but little is known about why 10% are resistant. Here, the authors explore the potential underlying mechanisms by probing the genomic landscape of platinum-resistant disease. |
| format |
article |
| author |
Chey Loveday Kevin Litchfield Paula Z. Proszek Alex J. Cornish Flavia Santo Max Levy Geoff Macintyre Amy Holryod Peter Broderick Darshna Dudakia Barbara Benton Maise Al Bakir Crispin Hiley Emily Grist Charles Swanton Robert Huddart Tom Powles Simon Chowdhury Janet Shipley Simon O’Connor James D. Brenton Alison Reid David Gonzalez de Castro Richard S. Houlston Clare Turnbull |
| author_facet |
Chey Loveday Kevin Litchfield Paula Z. Proszek Alex J. Cornish Flavia Santo Max Levy Geoff Macintyre Amy Holryod Peter Broderick Darshna Dudakia Barbara Benton Maise Al Bakir Crispin Hiley Emily Grist Charles Swanton Robert Huddart Tom Powles Simon Chowdhury Janet Shipley Simon O’Connor James D. Brenton Alison Reid David Gonzalez de Castro Richard S. Houlston Clare Turnbull |
| author_sort |
Chey Loveday |
| title |
Genomic landscape of platinum resistant and sensitive testicular cancers |
| title_short |
Genomic landscape of platinum resistant and sensitive testicular cancers |
| title_full |
Genomic landscape of platinum resistant and sensitive testicular cancers |
| title_fullStr |
Genomic landscape of platinum resistant and sensitive testicular cancers |
| title_full_unstemmed |
Genomic landscape of platinum resistant and sensitive testicular cancers |
| title_sort |
genomic landscape of platinum resistant and sensitive testicular cancers |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/fd830b167ba2414b9bc17a0f92cc02a5 |
| work_keys_str_mv |
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1718389669155045376 |