HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction

Type I Interferon is thought to be a driving force for immune activation and T cell exhaustion during HIV infection. Here the authors show that intron-containing HIV RNA induces innate immune activation resulting in associated T cell dysfunction.

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Autores principales: Hisashi Akiyama, Caitlin M. Miller, Chelsea R. Ettinger, Anna C. Belkina, Jennifer E. Snyder-Cappione, Suryaram Gummuluru
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/fd9ffab4b9f44e5a8e33aca631a09672
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