HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction

Type I Interferon is thought to be a driving force for immune activation and T cell exhaustion during HIV infection. Here the authors show that intron-containing HIV RNA induces innate immune activation resulting in associated T cell dysfunction.

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Autores principales:	Hisashi Akiyama, Caitlin M. Miller, Chelsea R. Ettinger, Anna C. Belkina, Jennifer E. Snyder-Cappione, Suryaram Gummuluru
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fd9ffab4b9f44e5a8e33aca631a09672
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spelling	oai:doaj.org-article:fd9ffab4b9f44e5a8e33aca631a096722021-12-02T14:39:45ZHIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction10.1038/s41467-018-05899-72041-1723https://doaj.org/article/fd9ffab4b9f44e5a8e33aca631a096722018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05899-7https://doaj.org/toc/2041-1723Type I Interferon is thought to be a driving force for immune activation and T cell exhaustion during HIV infection. Here the authors show that intron-containing HIV RNA induces innate immune activation resulting in associated T cell dysfunction.Hisashi AkiyamaCaitlin M. MillerChelsea R. EttingerAnna C. BelkinaJennifer E. Snyder-CappioneSuryaram GummuluruNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hisashi Akiyama Caitlin M. Miller Chelsea R. Ettinger Anna C. Belkina Jennifer E. Snyder-Cappione Suryaram Gummuluru HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction
description	Type I Interferon is thought to be a driving force for immune activation and T cell exhaustion during HIV infection. Here the authors show that intron-containing HIV RNA induces innate immune activation resulting in associated T cell dysfunction.
format	article
author	Hisashi Akiyama Caitlin M. Miller Chelsea R. Ettinger Anna C. Belkina Jennifer E. Snyder-Cappione Suryaram Gummuluru
author_facet	Hisashi Akiyama Caitlin M. Miller Chelsea R. Ettinger Anna C. Belkina Jennifer E. Snyder-Cappione Suryaram Gummuluru
author_sort	Hisashi Akiyama
title	HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction
title_short	HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction
title_full	HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction
title_fullStr	HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction
title_full_unstemmed	HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction
title_sort	hiv-1 intron-containing rna expression induces innate immune activation and t cell dysfunction
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fd9ffab4b9f44e5a8e33aca631a09672
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HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction

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