HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction
Type I Interferon is thought to be a driving force for immune activation and T cell exhaustion during HIV infection. Here the authors show that intron-containing HIV RNA induces innate immune activation resulting in associated T cell dysfunction.
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Auteurs principaux: | Hisashi Akiyama, Caitlin M. Miller, Chelsea R. Ettinger, Anna C. Belkina, Jennifer E. Snyder-Cappione, Suryaram Gummuluru |
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Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2018
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Sujets: | |
Accès en ligne: | https://doaj.org/article/fd9ffab4b9f44e5a8e33aca631a09672 |
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