Synthesis of Polypeptides with High-Fidelity Terminal Functionalities under NCA Monomer-Starved Conditions
Controlled polypeptide synthesis via α-amino acid N-carboxylic anhydride (NCA) polymerization using conventional primary amine initiators encounters two major obstacles: (i) normal amine mechanism (NAM) and activated monomer mechanism (AMM) coexist due to amine basicity and nucleophilicity and (ii)...
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Autores principales: | , , , , , , , |
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Formato: | article |
Lenguaje: | EN |
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American Association for the Advancement of Science
2021
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Acceso en línea: | https://doaj.org/article/fdd4b9990a01414e8b470d074ea53dfa |
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