Synthesis of Polypeptides with High-Fidelity Terminal Functionalities under NCA Monomer-Starved Conditions

Synthesis of Polypeptides with High-Fidelity Terminal Functionalities under NCA Monomer-Starved Conditions

Controlled polypeptide synthesis via α-amino acid N-carboxylic anhydride (NCA) polymerization using conventional primary amine initiators encounters two major obstacles: (i) normal amine mechanism (NAM) and activated monomer mechanism (AMM) coexist due to amine basicity and nucleophilicity and (ii)...

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Autores principales: Lei Li, Jie Cen, Wenhao Pan, Yuben Zhang, Xuanxi Leng, Zhengqi Tan, Hao Yin, Shiyong Liu
Formato: article
Lenguaje:EN
Publicado: American Association for the Advancement of Science 2021
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Acceso en línea:https://doaj.org/article/fdd4b9990a01414e8b470d074ea53dfa
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