Rhesus TRIM5α disrupts the HIV-1 capsid at the inter-hexamer interfaces.

TRIM proteins play important roles in the innate immune defense against retroviral infection, including human immunodeficiency virus type-1 (HIV-1). Rhesus macaque TRIM5α (TRIM5α(rh)) targets the HIV-1 capsid and blocks infection at an early post-entry stage, prior to reverse transcription. Studies...

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Autores principales: Gongpu Zhao, Danxia Ke, Thomas Vu, Jinwoo Ahn, Vaibhav B Shah, Ruifeng Yang, Christopher Aiken, Lisa M Charlton, Angela M Gronenborn, Peijun Zhang
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/fdf7626b6bc34083ba2352640dadd6bb
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