Theoretical and experimental studies of new modified isoflavonoids as potential inhibitors of topoisomerase I from Plasmodium falciparum.

Theoretical and experimental studies of new modified isoflavonoids as potential inhibitors of topoisomerase I from Plasmodium falciparum.

DNA topoisomerase I from Plasmodium falciparum (PfTopoI), a potential selective target for chemotherapy and drug development against malaria, is used here, together with human Topo I (HssTopoI), for docking, molecular dynamics (MD) studies and experimental assays. Six synthetic isoflavonoid derivati...

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Autores principales: Wilian A Cortopassi, Julia Penna-Coutinho, Anna C C Aguiar, André S Pimentel, Camilla D Buarque, Paulo R R Costa, Bruna R M Alves, Tanos C C França, Antoniana U Krettli
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/fdfc16d0a2f848da92672d1df059ed90
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https://doaj.org/article/fdfc16d0a2f848da92672d1df059ed90

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