Tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response

Petreus et al. describe a platform combining 3D tumour-on-chip technology and pump driven microfluidics to study drug effects at physiological exposures preclinically. They test colorectal cancer spheroids with combinations of two drugs and show that it can successfully predict efficacy in vivo, the...

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Auteurs principaux: Tudor Petreus, Elaine Cadogan, Gareth Hughes, Aaron Smith, Venkatesh Pilla Reddy, Alan Lau, Mark James O’Connor, Susan Critchlow, Marianne Ashford, Lenka Oplustil O’Connor
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/fe393dff3e4d4995a5151b725bf099ec
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