Tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response

Petreus et al. describe a platform combining 3D tumour-on-chip technology and pump driven microfluidics to study drug effects at physiological exposures preclinically. They test colorectal cancer spheroids with combinations of two drugs and show that it can successfully predict efficacy in vivo, the...

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Autores principales:	Tudor Petreus, Elaine Cadogan, Gareth Hughes, Aaron Smith, Venkatesh Pilla Reddy, Alan Lau, Mark James O’Connor, Susan Critchlow, Marianne Ashford, Lenka Oplustil O’Connor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/fe393dff3e4d4995a5151b725bf099ec
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spelling	oai:doaj.org-article:fe393dff3e4d4995a5151b725bf099ec2021-12-02T16:35:05ZTumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response10.1038/s42003-021-02526-y2399-3642https://doaj.org/article/fe393dff3e4d4995a5151b725bf099ec2021-08-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02526-yhttps://doaj.org/toc/2399-3642Petreus et al. describe a platform combining 3D tumour-on-chip technology and pump driven microfluidics to study drug effects at physiological exposures preclinically. They test colorectal cancer spheroids with combinations of two drugs and show that it can successfully predict efficacy in vivo, thereby providing a valuable tool for drug response and pharmacodynamic assessment and reducing the need for animal studies.Tudor PetreusElaine CadoganGareth HughesAaron SmithVenkatesh Pilla ReddyAlan LauMark James O’ConnorSusan CritchlowMarianne AshfordLenka Oplustil O’ConnorNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Tudor Petreus Elaine Cadogan Gareth Hughes Aaron Smith Venkatesh Pilla Reddy Alan Lau Mark James O’Connor Susan Critchlow Marianne Ashford Lenka Oplustil O’Connor Tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response
description	Petreus et al. describe a platform combining 3D tumour-on-chip technology and pump driven microfluidics to study drug effects at physiological exposures preclinically. They test colorectal cancer spheroids with combinations of two drugs and show that it can successfully predict efficacy in vivo, thereby providing a valuable tool for drug response and pharmacodynamic assessment and reducing the need for animal studies.
format	article
author	Tudor Petreus Elaine Cadogan Gareth Hughes Aaron Smith Venkatesh Pilla Reddy Alan Lau Mark James O’Connor Susan Critchlow Marianne Ashford Lenka Oplustil O’Connor
author_facet	Tudor Petreus Elaine Cadogan Gareth Hughes Aaron Smith Venkatesh Pilla Reddy Alan Lau Mark James O’Connor Susan Critchlow Marianne Ashford Lenka Oplustil O’Connor
author_sort	Tudor Petreus
title	Tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response
title_short	Tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response
title_full	Tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response
title_fullStr	Tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response
title_full_unstemmed	Tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response
title_sort	tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fe393dff3e4d4995a5151b725bf099ec
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Tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response

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