Modulation and Pharmacology of the Mitochondrial Permeability Transition: A Journey from F-ATP Synthase to ANT

The permeability transition (PT) is an increased permeation of the inner mitochondrial membrane due to the opening of the PT pore (PTP), a Ca<sup>2+</sup>-activated high conductance channel involved in Ca<sup>2+</sup> homeostasis and cell death. Alterations of the PTP have be...

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Autores principales:	Andrea Carrer, Claudio Laquatra, Ludovica Tommasin, Michela Carraro
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	permeability transition calcium F-ATP synthase adenine nucleotide translocator cyclophilin D mitochondrial channels Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/fe3c2f7d65894b47a6f200869f31c7ba
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spelling	oai:doaj.org-article:fe3c2f7d65894b47a6f200869f31c7ba2021-11-11T18:28:19ZModulation and Pharmacology of the Mitochondrial Permeability Transition: A Journey from F-ATP Synthase to ANT10.3390/molecules262164631420-3049https://doaj.org/article/fe3c2f7d65894b47a6f200869f31c7ba2021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6463https://doaj.org/toc/1420-3049The permeability transition (PT) is an increased permeation of the inner mitochondrial membrane due to the opening of the PT pore (PTP), a Ca<sup>2+</sup>-activated high conductance channel involved in Ca<sup>2+</sup> homeostasis and cell death. Alterations of the PTP have been associated with many pathological conditions and its targeting represents an incessant challenge in the field. Although the modulation of the PTP has been extensively explored, the lack of a clear picture of its molecular nature increases the degree of complexity for any target-based approach. Recent advances suggest the existence of at least two mitochondrial permeability pathways mediated by the F-ATP synthase and the ANT, although the exact molecular mechanism leading to channel formation remains elusive for both. A full comprehension of this to-pore conversion will help to assist in drug design and to develop pharmacological treatments for a fine-tuned PT regulation. Here, we will focus on regulatory mechanisms that impinge on the PTP and discuss the relevant literature of PTP targeting compounds with particular attention to F-ATP synthase and ANT.Andrea CarrerClaudio LaquatraLudovica TommasinMichela CarraroMDPI AGarticlepermeability transitioncalciumF-ATP synthaseadenine nucleotide translocatorcyclophilin Dmitochondrial channelsOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6463, p 6463 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	permeability transition calcium F-ATP synthase adenine nucleotide translocator cyclophilin D mitochondrial channels Organic chemistry QD241-441
spellingShingle	permeability transition calcium F-ATP synthase adenine nucleotide translocator cyclophilin D mitochondrial channels Organic chemistry QD241-441 Andrea Carrer Claudio Laquatra Ludovica Tommasin Michela Carraro Modulation and Pharmacology of the Mitochondrial Permeability Transition: A Journey from F-ATP Synthase to ANT
description	The permeability transition (PT) is an increased permeation of the inner mitochondrial membrane due to the opening of the PT pore (PTP), a Ca<sup>2+</sup>-activated high conductance channel involved in Ca<sup>2+</sup> homeostasis and cell death. Alterations of the PTP have been associated with many pathological conditions and its targeting represents an incessant challenge in the field. Although the modulation of the PTP has been extensively explored, the lack of a clear picture of its molecular nature increases the degree of complexity for any target-based approach. Recent advances suggest the existence of at least two mitochondrial permeability pathways mediated by the F-ATP synthase and the ANT, although the exact molecular mechanism leading to channel formation remains elusive for both. A full comprehension of this to-pore conversion will help to assist in drug design and to develop pharmacological treatments for a fine-tuned PT regulation. Here, we will focus on regulatory mechanisms that impinge on the PTP and discuss the relevant literature of PTP targeting compounds with particular attention to F-ATP synthase and ANT.
format	article
author	Andrea Carrer Claudio Laquatra Ludovica Tommasin Michela Carraro
author_facet	Andrea Carrer Claudio Laquatra Ludovica Tommasin Michela Carraro
author_sort	Andrea Carrer
title	Modulation and Pharmacology of the Mitochondrial Permeability Transition: A Journey from F-ATP Synthase to ANT
title_short	Modulation and Pharmacology of the Mitochondrial Permeability Transition: A Journey from F-ATP Synthase to ANT
title_full	Modulation and Pharmacology of the Mitochondrial Permeability Transition: A Journey from F-ATP Synthase to ANT
title_fullStr	Modulation and Pharmacology of the Mitochondrial Permeability Transition: A Journey from F-ATP Synthase to ANT
title_full_unstemmed	Modulation and Pharmacology of the Mitochondrial Permeability Transition: A Journey from F-ATP Synthase to ANT
title_sort	modulation and pharmacology of the mitochondrial permeability transition: a journey from f-atp synthase to ant
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/fe3c2f7d65894b47a6f200869f31c7ba
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Modulation and Pharmacology of the Mitochondrial Permeability Transition: A Journey from F-ATP Synthase to ANT

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