BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma

Amongst the non-small cell lung cancers, to date, lung squamous cell carcinoma remains the most challenging to treat. Here the authors report BCL11A as an important factor which together with SOX2 can drive lung squamous cell carcinoma development and highlight a potential novel therapeutic candidat...

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Autores principales: Kyren A. Lazarus, Fazal Hadi, Elisabetta Zambon, Karsten Bach, Maria-Francesca Santolla, Julie K. Watson, Lucia L. Correia, Madhumita Das, Rosemary Ugur, Sara Pensa, Lukas Becker, Lia S. Campos, Graham Ladds, Pentao Liu, Gerard I. Evan, Frank M. McCaughan, John Le Quesne, Joo-Hyeon Lee, Dinis Calado, Walid T. Khaled
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Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/fe3fa86c37864591b2b0b229a1e43f44
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spelling oai:doaj.org-article:fe3fa86c37864591b2b0b229a1e43f442021-12-02T15:33:54ZBCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma10.1038/s41467-018-05790-52041-1723https://doaj.org/article/fe3fa86c37864591b2b0b229a1e43f442018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05790-5https://doaj.org/toc/2041-1723Amongst the non-small cell lung cancers, to date, lung squamous cell carcinoma remains the most challenging to treat. Here the authors report BCL11A as an important factor which together with SOX2 can drive lung squamous cell carcinoma development and highlight a potential novel therapeutic candidate for this devastating disease.Kyren A. LazarusFazal HadiElisabetta ZambonKarsten BachMaria-Francesca SantollaJulie K. WatsonLucia L. CorreiaMadhumita DasRosemary UgurSara PensaLukas BeckerLia S. CamposGraham LaddsPentao LiuGerard I. EvanFrank M. McCaughanJohn Le QuesneJoo-Hyeon LeeDinis CaladoWalid T. KhaledNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kyren A. Lazarus
Fazal Hadi
Elisabetta Zambon
Karsten Bach
Maria-Francesca Santolla
Julie K. Watson
Lucia L. Correia
Madhumita Das
Rosemary Ugur
Sara Pensa
Lukas Becker
Lia S. Campos
Graham Ladds
Pentao Liu
Gerard I. Evan
Frank M. McCaughan
John Le Quesne
Joo-Hyeon Lee
Dinis Calado
Walid T. Khaled
BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma
description Amongst the non-small cell lung cancers, to date, lung squamous cell carcinoma remains the most challenging to treat. Here the authors report BCL11A as an important factor which together with SOX2 can drive lung squamous cell carcinoma development and highlight a potential novel therapeutic candidate for this devastating disease.
format article
author Kyren A. Lazarus
Fazal Hadi
Elisabetta Zambon
Karsten Bach
Maria-Francesca Santolla
Julie K. Watson
Lucia L. Correia
Madhumita Das
Rosemary Ugur
Sara Pensa
Lukas Becker
Lia S. Campos
Graham Ladds
Pentao Liu
Gerard I. Evan
Frank M. McCaughan
John Le Quesne
Joo-Hyeon Lee
Dinis Calado
Walid T. Khaled
author_facet Kyren A. Lazarus
Fazal Hadi
Elisabetta Zambon
Karsten Bach
Maria-Francesca Santolla
Julie K. Watson
Lucia L. Correia
Madhumita Das
Rosemary Ugur
Sara Pensa
Lukas Becker
Lia S. Campos
Graham Ladds
Pentao Liu
Gerard I. Evan
Frank M. McCaughan
John Le Quesne
Joo-Hyeon Lee
Dinis Calado
Walid T. Khaled
author_sort Kyren A. Lazarus
title BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma
title_short BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma
title_full BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma
title_fullStr BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma
title_full_unstemmed BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma
title_sort bcl11a interacts with sox2 to control the expression of epigenetic regulators in lung squamous carcinoma
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/fe3fa86c37864591b2b0b229a1e43f44
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