Genome-wide identification of directed gene networks using large-scale population genomics data

Identification of causal drivers behind expression is essential for understanding gene function. Here authors develop a method for the large-scale inference of gene–gene interactions in observational population genomics data and characterize a network of trans-effects for 6600 genes.

Guardado en:

Detalles Bibliográficos
Autores principales:	René Luijk, Koen F. Dekkers, Maarten van Iterson, Wibowo Arindrarto, Annique Claringbould, Paul Hop, Dorret I. Boomsma, Cornelia M. van Duijn, Marleen M. J. van Greevenbroek, Jan H. Veldink, Cisca Wijmenga, Lude Franke, Peter A. C. ’t Hoen, Rick Jansen, Joyce van Meurs, Hailiang Mei, P. Eline Slagboom, Bastiaan T. Heijmans, Erik W. van Zwet, BIOS (Biobank-based Integrative Omics Study) Consortium
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fe4640ea326848b3a9330f5cfa121bef
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fe4640ea326848b3a9330f5cfa121bef
record_format	dspace
spelling	oai:doaj.org-article:fe4640ea326848b3a9330f5cfa121bef2021-12-02T14:40:08ZGenome-wide identification of directed gene networks using large-scale population genomics data10.1038/s41467-018-05452-62041-1723https://doaj.org/article/fe4640ea326848b3a9330f5cfa121bef2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05452-6https://doaj.org/toc/2041-1723Identification of causal drivers behind expression is essential for understanding gene function. Here authors develop a method for the large-scale inference of gene–gene interactions in observational population genomics data and characterize a network of trans-effects for 6600 genes.René LuijkKoen F. DekkersMaarten van ItersonWibowo ArindrartoAnnique ClaringbouldPaul HopDorret I. BoomsmaCornelia M. van DuijnMarleen M. J. van GreevenbroekJan H. VeldinkCisca WijmengaLude FrankePeter A. C. ’t HoenRick JansenJoyce van MeursHailiang MeiP. Eline SlagboomBastiaan T. HeijmansErik W. van ZwetBIOS (Biobank-based Integrative Omics Study) ConsortiumNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q René Luijk Koen F. Dekkers Maarten van Iterson Wibowo Arindrarto Annique Claringbould Paul Hop Dorret I. Boomsma Cornelia M. van Duijn Marleen M. J. van Greevenbroek Jan H. Veldink Cisca Wijmenga Lude Franke Peter A. C. ’t Hoen Rick Jansen Joyce van Meurs Hailiang Mei P. Eline Slagboom Bastiaan T. Heijmans Erik W. van Zwet BIOS (Biobank-based Integrative Omics Study) Consortium Genome-wide identification of directed gene networks using large-scale population genomics data
description	Identification of causal drivers behind expression is essential for understanding gene function. Here authors develop a method for the large-scale inference of gene–gene interactions in observational population genomics data and characterize a network of trans-effects for 6600 genes.
format	article
author	René Luijk Koen F. Dekkers Maarten van Iterson Wibowo Arindrarto Annique Claringbould Paul Hop Dorret I. Boomsma Cornelia M. van Duijn Marleen M. J. van Greevenbroek Jan H. Veldink Cisca Wijmenga Lude Franke Peter A. C. ’t Hoen Rick Jansen Joyce van Meurs Hailiang Mei P. Eline Slagboom Bastiaan T. Heijmans Erik W. van Zwet BIOS (Biobank-based Integrative Omics Study) Consortium
author_facet	René Luijk Koen F. Dekkers Maarten van Iterson Wibowo Arindrarto Annique Claringbould Paul Hop Dorret I. Boomsma Cornelia M. van Duijn Marleen M. J. van Greevenbroek Jan H. Veldink Cisca Wijmenga Lude Franke Peter A. C. ’t Hoen Rick Jansen Joyce van Meurs Hailiang Mei P. Eline Slagboom Bastiaan T. Heijmans Erik W. van Zwet BIOS (Biobank-based Integrative Omics Study) Consortium
author_sort	René Luijk
title	Genome-wide identification of directed gene networks using large-scale population genomics data
title_short	Genome-wide identification of directed gene networks using large-scale population genomics data
title_full	Genome-wide identification of directed gene networks using large-scale population genomics data
title_fullStr	Genome-wide identification of directed gene networks using large-scale population genomics data
title_full_unstemmed	Genome-wide identification of directed gene networks using large-scale population genomics data
title_sort	genome-wide identification of directed gene networks using large-scale population genomics data
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fe4640ea326848b3a9330f5cfa121bef
work_keys_str_mv	AT reneluijk genomewideidentificationofdirectedgenenetworksusinglargescalepopulationgenomicsdata AT koenfdekkers genomewideidentificationofdirectedgenenetworksusinglargescalepopulationgenomicsdata AT maartenvaniterson genomewideidentificationofdirectedgenenetworksusinglargescalepopulationgenomicsdata AT wibowoarindrarto genomewideidentificationofdirectedgenenetworksusinglargescalepopulationgenomicsdata AT anniqueclaringbould genomewideidentificationofdirectedgenenetworksusinglargescalepopulationgenomicsdata AT paulhop genomewideidentificationofdirectedgenenetworksusinglargescalepopulationgenomicsdata AT dorretiboomsma genomewideidentificationofdirectedgenenetworksusinglargescalepopulationgenomicsdata AT corneliamvanduijn genomewideidentificationofdirectedgenenetworksusinglargescalepopulationgenomicsdata AT marleenmjvangreevenbroek genomewideidentificationofdirectedgenenetworksusinglargescalepopulationgenomicsdata AT janhveldink genomewideidentificationofdirectedgenenetworksusinglargescalepopulationgenomicsdata AT ciscawijmenga genomewideidentificationofdirectedgenenetworksusinglargescalepopulationgenomicsdata AT ludefranke genomewideidentificationofdirectedgenenetworksusinglargescalepopulationgenomicsdata AT peteracthoen genomewideidentificationofdirectedgenenetworksusinglargescalepopulationgenomicsdata AT rickjansen genomewideidentificationofdirectedgenenetworksusinglargescalepopulationgenomicsdata AT joycevanmeurs genomewideidentificationofdirectedgenenetworksusinglargescalepopulationgenomicsdata AT hailiangmei genomewideidentificationofdirectedgenenetworksusinglargescalepopulationgenomicsdata AT pelineslagboom genomewideidentificationofdirectedgenenetworksusinglargescalepopulationgenomicsdata AT bastiaantheijmans genomewideidentificationofdirectedgenenetworksusinglargescalepopulationgenomicsdata AT erikwvanzwet genomewideidentificationofdirectedgenenetworksusinglargescalepopulationgenomicsdata AT biosbiobankbasedintegrativeomicsstudyconsortium genomewideidentificationofdirectedgenenetworksusinglargescalepopulationgenomicsdata
_version_	1718390455476944896

Genome-wide identification of directed gene networks using large-scale population genomics data

Ejemplares similares