Multidirectional desymmetrization of pluripotent building block en route to diastereoselective synthesis of complex nature-inspired scaffolds

Methods enabling the synthesis of diverse collections of nature-inspired compounds with potential medicinal use are sought after in drug design. Here, the authors report a build/couple/pair strategy to efficiently construct chiral polycyclic scaffolds and show their diversification for drug discover...

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Autores principales:	Vunnam Srinivasulu, Paul Schilf, Saleh Ibrahim, Monther A. Khanfar, Scott McN Sieburth, Hany Omar, Anusha Sebastian, Raed A. AlQawasmeh, Matthew John O’Connor, Taleb H. Al-Tel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fe4e0908a13b4e04b9750d85006dd424
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spelling	oai:doaj.org-article:fe4e0908a13b4e04b9750d85006dd4242021-12-02T14:39:48ZMultidirectional desymmetrization of pluripotent building block en route to diastereoselective synthesis of complex nature-inspired scaffolds10.1038/s41467-018-07521-22041-1723https://doaj.org/article/fe4e0908a13b4e04b9750d85006dd4242018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07521-2https://doaj.org/toc/2041-1723Methods enabling the synthesis of diverse collections of nature-inspired compounds with potential medicinal use are sought after in drug design. Here, the authors report a build/couple/pair strategy to efficiently construct chiral polycyclic scaffolds and show their diversification for drug discovery screening.Vunnam SrinivasuluPaul SchilfSaleh IbrahimMonther A. KhanfarScott McN SieburthHany OmarAnusha SebastianRaed A. AlQawasmehMatthew John O’ConnorTaleb H. Al-TelNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vunnam Srinivasulu Paul Schilf Saleh Ibrahim Monther A. Khanfar Scott McN Sieburth Hany Omar Anusha Sebastian Raed A. AlQawasmeh Matthew John O’Connor Taleb H. Al-Tel Multidirectional desymmetrization of pluripotent building block en route to diastereoselective synthesis of complex nature-inspired scaffolds
description	Methods enabling the synthesis of diverse collections of nature-inspired compounds with potential medicinal use are sought after in drug design. Here, the authors report a build/couple/pair strategy to efficiently construct chiral polycyclic scaffolds and show their diversification for drug discovery screening.
format	article
author	Vunnam Srinivasulu Paul Schilf Saleh Ibrahim Monther A. Khanfar Scott McN Sieburth Hany Omar Anusha Sebastian Raed A. AlQawasmeh Matthew John O’Connor Taleb H. Al-Tel
author_facet	Vunnam Srinivasulu Paul Schilf Saleh Ibrahim Monther A. Khanfar Scott McN Sieburth Hany Omar Anusha Sebastian Raed A. AlQawasmeh Matthew John O’Connor Taleb H. Al-Tel
author_sort	Vunnam Srinivasulu
title	Multidirectional desymmetrization of pluripotent building block en route to diastereoselective synthesis of complex nature-inspired scaffolds
title_short	Multidirectional desymmetrization of pluripotent building block en route to diastereoselective synthesis of complex nature-inspired scaffolds
title_full	Multidirectional desymmetrization of pluripotent building block en route to diastereoselective synthesis of complex nature-inspired scaffolds
title_fullStr	Multidirectional desymmetrization of pluripotent building block en route to diastereoselective synthesis of complex nature-inspired scaffolds
title_full_unstemmed	Multidirectional desymmetrization of pluripotent building block en route to diastereoselective synthesis of complex nature-inspired scaffolds
title_sort	multidirectional desymmetrization of pluripotent building block en route to diastereoselective synthesis of complex nature-inspired scaffolds
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fe4e0908a13b4e04b9750d85006dd424
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Multidirectional desymmetrization of pluripotent building block en route to diastereoselective synthesis of complex nature-inspired scaffolds

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