Key Positions of HIV-1 Env and Signatures of Vaccine Efficacy Show Gradual Reduction of Population Founder Effects at the Clade and Regional Levels

Key Positions of HIV-1 Env and Signatures of Vaccine Efficacy Show Gradual Reduction of Population Founder Effects at the Clade and Regional Levels

ABSTRACT HIV-1 group M was transmitted to humans nearly one century ago. The virus has since evolved to form distinct clades, which spread to different regions of the world. The envelope glycoproteins (Envs) of HIV-1 have rapidly diversified in all infected populations. We examined whether key antig...

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Autores principales: Changze Han, Jacklyn Johnson, Rentian Dong, Raghavendranath Kandula, Alexa Kort, Maria Wong, Tianbao Yang, Patrick J. Breheny, Grant D. Brown, Hillel Haim
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
HIV-1
envelope glycoproteins
population-level evolution
vaccine design
virus diversity
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/fe643beff6824ed7bea672931542a0f5
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https://doaj.org/article/fe643beff6824ed7bea672931542a0f5

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