BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity

The loss of homologous recombination (HR) genes such as BRCA1 and BRCA2 is deleterious to the survival of normal cells, yet it is tolerated in cancer cells. Here the authors identify TNFα signaling as a determinant of viability in BRCA2- inactivated cancer cells.

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Autores principales:	Anne Margriet Heijink, Francien Talens, Lucas T. Jae, Stephanie E. van Gijn, Rudolf S. N. Fehrmann, Thijn R. Brummelkamp, Marcel A. T. M. van Vugt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fe87c5673305416fa0c30e5631b208ed
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spelling	oai:doaj.org-article:fe87c5673305416fa0c30e5631b208ed2021-12-02T16:57:10ZBRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity10.1038/s41467-018-07927-y2041-1723https://doaj.org/article/fe87c5673305416fa0c30e5631b208ed2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07927-yhttps://doaj.org/toc/2041-1723The loss of homologous recombination (HR) genes such as BRCA1 and BRCA2 is deleterious to the survival of normal cells, yet it is tolerated in cancer cells. Here the authors identify TNFα signaling as a determinant of viability in BRCA2- inactivated cancer cells.Anne Margriet HeijinkFrancien TalensLucas T. JaeStephanie E. van GijnRudolf S. N. FehrmannThijn R. BrummelkampMarcel A. T. M. van VugtNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anne Margriet Heijink Francien Talens Lucas T. Jae Stephanie E. van Gijn Rudolf S. N. Fehrmann Thijn R. Brummelkamp Marcel A. T. M. van Vugt BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity
description	The loss of homologous recombination (HR) genes such as BRCA1 and BRCA2 is deleterious to the survival of normal cells, yet it is tolerated in cancer cells. Here the authors identify TNFα signaling as a determinant of viability in BRCA2- inactivated cancer cells.
format	article
author	Anne Margriet Heijink Francien Talens Lucas T. Jae Stephanie E. van Gijn Rudolf S. N. Fehrmann Thijn R. Brummelkamp Marcel A. T. M. van Vugt
author_facet	Anne Margriet Heijink Francien Talens Lucas T. Jae Stephanie E. van Gijn Rudolf S. N. Fehrmann Thijn R. Brummelkamp Marcel A. T. M. van Vugt
author_sort	Anne Margriet Heijink
title	BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity
title_short	BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity
title_full	BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity
title_fullStr	BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity
title_full_unstemmed	BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity
title_sort	brca2 deficiency instigates cgas-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/fe87c5673305416fa0c30e5631b208ed
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BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity

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