Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins

The innate immune system and inflammation modulate bone homeostasis through complex regulation of bone remodelling cells including osteoblasts and osteoclasts. Here, the authors show that the type I interferon pathway and guanylate binding proteins functionally limit bone loss by inhibiting osteocla...

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Bibliographic Details
Main Authors: David E. Place, R. K. Subbarao Malireddi, Jieun Kim, Peter Vogel, Masahiro Yamamoto, Thirumala-Devi Kanneganti
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/fea52b57d5b54778a319077014717dd0
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