Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins

The innate immune system and inflammation modulate bone homeostasis through complex regulation of bone remodelling cells including osteoblasts and osteoclasts. Here, the authors show that the type I interferon pathway and guanylate binding proteins functionally limit bone loss by inhibiting osteocla...

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Autores principales:	David E. Place, R. K. Subbarao Malireddi, Jieun Kim, Peter Vogel, Masahiro Yamamoto, Thirumala-Devi Kanneganti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fea52b57d5b54778a319077014717dd0
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spelling	oai:doaj.org-article:fea52b57d5b54778a319077014717dd02021-12-02T14:19:11ZOsteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins10.1038/s41467-020-20807-82041-1723https://doaj.org/article/fea52b57d5b54778a319077014717dd02021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20807-8https://doaj.org/toc/2041-1723The innate immune system and inflammation modulate bone homeostasis through complex regulation of bone remodelling cells including osteoblasts and osteoclasts. Here, the authors show that the type I interferon pathway and guanylate binding proteins functionally limit bone loss by inhibiting osteoclast functions.David E. PlaceR. K. Subbarao MalireddiJieun KimPeter VogelMasahiro YamamotoThirumala-Devi KannegantiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David E. Place R. K. Subbarao Malireddi Jieun Kim Peter Vogel Masahiro Yamamoto Thirumala-Devi Kanneganti Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins
description	The innate immune system and inflammation modulate bone homeostasis through complex regulation of bone remodelling cells including osteoblasts and osteoclasts. Here, the authors show that the type I interferon pathway and guanylate binding proteins functionally limit bone loss by inhibiting osteoclast functions.
format	article
author	David E. Place R. K. Subbarao Malireddi Jieun Kim Peter Vogel Masahiro Yamamoto Thirumala-Devi Kanneganti
author_facet	David E. Place R. K. Subbarao Malireddi Jieun Kim Peter Vogel Masahiro Yamamoto Thirumala-Devi Kanneganti
author_sort	David E. Place
title	Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins
title_short	Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins
title_full	Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins
title_fullStr	Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins
title_full_unstemmed	Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins
title_sort	osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fea52b57d5b54778a319077014717dd0
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_version_	1718391643813445632

Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins

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