Bistability in fatty-acid oxidation resulting from substrate inhibition.

In this study we demonstrated through analytic considerations and numerical studies that the mitochondrial fatty-acid β-oxidation can exhibit bistable-hysteresis behavior. In an experimentally validated computational model we identified a specific region in the parameter space in which two distinct...

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Autores principales: Fentaw Abegaz, Anne-Claire M F Martines, Marcel A Vieira-Lara, Melany Rios-Morales, Dirk-Jan Reijngoud, Ernst C Wit, Barbara M Bakker
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/febc2d2c3e1e4399b08b47a1554814cc
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