Force-clamp spectroscopy identifies a catch bond mechanism in a Gram-positive pathogen

During colonization of host tissues and biomaterials, staphylococci are exposed to extreme mechanical forces. Here authors use force-clamp spectroscopy and show that the dock, lock and latch interaction between staphylococcal surface protein SpsD and fibrinogen is extremely strong, and exhibits an u...

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Bibliographic Details
Main Authors: Marion Mathelié-Guinlet, Felipe Viela, Giampiero Pietrocola, Pietro Speziale, David Alsteens, Yves F. Dufrêne
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/feca3bc0c89c4e12a02e7b8246148655
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