Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity

Inhibitory interneurons play important roles in brain circuits and in several neuropsychiatric disorders. Here, the authors show that excitatory synapses onto interneurons vs. excitatory neurons differ in their ambient synaptic glutamate level, a finding with important implications for selective pha...

Description complète

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Lulu Yao, Teddy Grand, Jesse E. Hanson, Pierre Paoletti, Qiang Zhou
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/feefe7905a1e4c1d9eb779cab0b0b4a6
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

id	oai:doaj.org-article:feefe7905a1e4c1d9eb779cab0b0b4a6
record_format	dspace
spelling	oai:doaj.org-article:feefe7905a1e4c1d9eb779cab0b0b4a62021-12-02T16:49:49ZHigher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity10.1038/s41467-018-06512-72041-1723https://doaj.org/article/feefe7905a1e4c1d9eb779cab0b0b4a62018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06512-7https://doaj.org/toc/2041-1723Inhibitory interneurons play important roles in brain circuits and in several neuropsychiatric disorders. Here, the authors show that excitatory synapses onto interneurons vs. excitatory neurons differ in their ambient synaptic glutamate level, a finding with important implications for selective pharmacological targeting of inhibitory neuron NMDA receptors.Lulu YaoTeddy GrandJesse E. HansonPierre PaolettiQiang ZhouNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lulu Yao Teddy Grand Jesse E. Hanson Pierre Paoletti Qiang Zhou Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity
description	Inhibitory interneurons play important roles in brain circuits and in several neuropsychiatric disorders. Here, the authors show that excitatory synapses onto interneurons vs. excitatory neurons differ in their ambient synaptic glutamate level, a finding with important implications for selective pharmacological targeting of inhibitory neuron NMDA receptors.
format	article
author	Lulu Yao Teddy Grand Jesse E. Hanson Pierre Paoletti Qiang Zhou
author_facet	Lulu Yao Teddy Grand Jesse E. Hanson Pierre Paoletti Qiang Zhou
author_sort	Lulu Yao
title	Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity
title_short	Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity
title_full	Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity
title_fullStr	Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity
title_full_unstemmed	Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity
title_sort	higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts nmda receptor activity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/feefe7905a1e4c1d9eb779cab0b0b4a6
work_keys_str_mv	AT luluyao higherambientsynapticglutamateatinhibitoryversusexcitatoryneuronsdifferentiallyimpactsnmdareceptoractivity AT teddygrand higherambientsynapticglutamateatinhibitoryversusexcitatoryneuronsdifferentiallyimpactsnmdareceptoractivity AT jesseehanson higherambientsynapticglutamateatinhibitoryversusexcitatoryneuronsdifferentiallyimpactsnmdareceptoractivity AT pierrepaoletti higherambientsynapticglutamateatinhibitoryversusexcitatoryneuronsdifferentiallyimpactsnmdareceptoractivity AT qiangzhou higherambientsynapticglutamateatinhibitoryversusexcitatoryneuronsdifferentiallyimpactsnmdareceptoractivity
_version_	1718383253821325312

Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity

Documents similaires