Revealing the structures of megadalton-scale DNA complexes with nucleotide resolution

Revealing the structures of megadalton-scale DNA complexes with nucleotide resolution

Precision design of DNA origami needs precision validation. Here, the authors developed cryo-EM methods for obtaining high resolution structural data and for constructing pseudo-atomic models in a semi-automated fashion, allowing for iterative nanodevice inspection and refinement.

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Detalles Bibliográficos
Autores principales: Massimo Kube, Fabian Kohler, Elija Feigl, Baki Nagel-Yüksel, Elena M. Willner, Jonas J. Funke, Thomas Gerling, Pierre Stömmer, Maximilian N. Honemann, Thomas G. Martin, Sjors H. W. Scheres, Hendrik Dietz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
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Acceso en línea:https://doaj.org/article/fef625b2e3904bd18533db01a9a93d13
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