Suppression of mucosal Th17 memory responses by acellular pertussis vaccines enhances nasal Bordetella pertussis carriage

Abstract Pertussis has made a spectacular rebound in countries that have switched from whole-cell (wPV) to acellular pertussis vaccines (aPV). Here, we show that, unlike wPV, aPV, while protective against lung colonization by Bordetella pertussis (Bp), did not protect BALB/c mice from nasal coloniza...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Violaine Dubois, Jonathan Chatagnon, Anaïs Thiriard, Hélène Bauderlique-Le Roy, Anne-Sophie Debrie, Loïc Coutte, Camille Locht
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/ff144e7514f74fce98731758573f1a89
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ff144e7514f74fce98731758573f1a89
record_format	dspace
spelling	oai:doaj.org-article:ff144e7514f74fce98731758573f1a892021-12-02T15:08:21ZSuppression of mucosal Th17 memory responses by acellular pertussis vaccines enhances nasal Bordetella pertussis carriage10.1038/s41541-020-00270-82059-0105https://doaj.org/article/ff144e7514f74fce98731758573f1a892021-01-01T00:00:00Zhttps://doi.org/10.1038/s41541-020-00270-8https://doaj.org/toc/2059-0105Abstract Pertussis has made a spectacular rebound in countries that have switched from whole-cell (wPV) to acellular pertussis vaccines (aPV). Here, we show that, unlike wPV, aPV, while protective against lung colonization by Bordetella pertussis (Bp), did not protect BALB/c mice from nasal colonization, but instead substantially prolonged nasal carriage. aPV prevented the natural induction of nasal interleukin-17 (IL-17)-producing and interferon-γ (IFN-γ)-producing CD103+ CD44+ CD69+ CD4+-resident memory T (TRM) cells. IL-17-deficient, but not IFN-γ-deficient, mice failed to clear nasal Bp, indicating a key role of IL-17+ TRM cells in the control of nasal infection. These cells appeared essential for neutrophil recruitment, crucial for clearance of Bp tightly bound to the nasal epithelium. Transfer of IL-17+ TRM cells from Bp-infected mice to IL-17-deficient mice resulted in neutrophil recruitment and protection against nasal colonization. Thus, aPV may have augmented the Bp reservoir by inhibiting natural TRM cell induction and neutrophil recruitment, thereby contributing to the pertussis resurgence.Violaine DuboisJonathan ChatagnonAnaïs ThiriardHélène Bauderlique-Le RoyAnne-Sophie DebrieLoïc CoutteCamille LochtNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 6, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Violaine Dubois Jonathan Chatagnon Anaïs Thiriard Hélène Bauderlique-Le Roy Anne-Sophie Debrie Loïc Coutte Camille Locht Suppression of mucosal Th17 memory responses by acellular pertussis vaccines enhances nasal Bordetella pertussis carriage
description	Abstract Pertussis has made a spectacular rebound in countries that have switched from whole-cell (wPV) to acellular pertussis vaccines (aPV). Here, we show that, unlike wPV, aPV, while protective against lung colonization by Bordetella pertussis (Bp), did not protect BALB/c mice from nasal colonization, but instead substantially prolonged nasal carriage. aPV prevented the natural induction of nasal interleukin-17 (IL-17)-producing and interferon-γ (IFN-γ)-producing CD103+ CD44+ CD69+ CD4+-resident memory T (TRM) cells. IL-17-deficient, but not IFN-γ-deficient, mice failed to clear nasal Bp, indicating a key role of IL-17+ TRM cells in the control of nasal infection. These cells appeared essential for neutrophil recruitment, crucial for clearance of Bp tightly bound to the nasal epithelium. Transfer of IL-17+ TRM cells from Bp-infected mice to IL-17-deficient mice resulted in neutrophil recruitment and protection against nasal colonization. Thus, aPV may have augmented the Bp reservoir by inhibiting natural TRM cell induction and neutrophil recruitment, thereby contributing to the pertussis resurgence.
format	article
author	Violaine Dubois Jonathan Chatagnon Anaïs Thiriard Hélène Bauderlique-Le Roy Anne-Sophie Debrie Loïc Coutte Camille Locht
author_facet	Violaine Dubois Jonathan Chatagnon Anaïs Thiriard Hélène Bauderlique-Le Roy Anne-Sophie Debrie Loïc Coutte Camille Locht
author_sort	Violaine Dubois
title	Suppression of mucosal Th17 memory responses by acellular pertussis vaccines enhances nasal Bordetella pertussis carriage
title_short	Suppression of mucosal Th17 memory responses by acellular pertussis vaccines enhances nasal Bordetella pertussis carriage
title_full	Suppression of mucosal Th17 memory responses by acellular pertussis vaccines enhances nasal Bordetella pertussis carriage
title_fullStr	Suppression of mucosal Th17 memory responses by acellular pertussis vaccines enhances nasal Bordetella pertussis carriage
title_full_unstemmed	Suppression of mucosal Th17 memory responses by acellular pertussis vaccines enhances nasal Bordetella pertussis carriage
title_sort	suppression of mucosal th17 memory responses by acellular pertussis vaccines enhances nasal bordetella pertussis carriage
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ff144e7514f74fce98731758573f1a89
work_keys_str_mv	AT violainedubois suppressionofmucosalth17memoryresponsesbyacellularpertussisvaccinesenhancesnasalbordetellapertussiscarriage AT jonathanchatagnon suppressionofmucosalth17memoryresponsesbyacellularpertussisvaccinesenhancesnasalbordetellapertussiscarriage AT anaisthiriard suppressionofmucosalth17memoryresponsesbyacellularpertussisvaccinesenhancesnasalbordetellapertussiscarriage AT helenebauderliqueleroy suppressionofmucosalth17memoryresponsesbyacellularpertussisvaccinesenhancesnasalbordetellapertussiscarriage AT annesophiedebrie suppressionofmucosalth17memoryresponsesbyacellularpertussisvaccinesenhancesnasalbordetellapertussiscarriage AT loiccoutte suppressionofmucosalth17memoryresponsesbyacellularpertussisvaccinesenhancesnasalbordetellapertussiscarriage AT camillelocht suppressionofmucosalth17memoryresponsesbyacellularpertussisvaccinesenhancesnasalbordetellapertussiscarriage
_version_	1718388230043205632

Suppression of mucosal Th17 memory responses by acellular pertussis vaccines enhances nasal Bordetella pertussis carriage

Ejemplares similares