Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation
Although IL-23 is expressed by psoriatic keratinocytes as well as immune cells, only the immune cell derived IL-23 is thought to be important for the development of psoriasis. Here the authors provide evidence that keratinocyte-produced IL-23 is sufficient to cause a chronic skin inflammation.
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Nature Portfolio
2018
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oai:doaj.org-article:ff608c11582641e39fc4e9d15e15de482021-12-02T16:49:19ZEpigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation10.1038/s41467-018-03704-z2041-1723https://doaj.org/article/ff608c11582641e39fc4e9d15e15de482018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03704-zhttps://doaj.org/toc/2041-1723Although IL-23 is expressed by psoriatic keratinocytes as well as immune cells, only the immune cell derived IL-23 is thought to be important for the development of psoriasis. Here the authors provide evidence that keratinocyte-produced IL-23 is sufficient to cause a chronic skin inflammation.Hui LiQi YaoAlberto Garcia MariscalXudong WuJustus HülseEsben PedersenKristian HelinAri WaismanCaroline VinkelSimon Francis ThomsenAlexandra AvgustinovaSalvador Aznar BenitahPaola LovatoHanne NorsgaardMette Sidsel MortensenLone VengBjörn RozellCord BrakebuschNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Hui Li Qi Yao Alberto Garcia Mariscal Xudong Wu Justus Hülse Esben Pedersen Kristian Helin Ari Waisman Caroline Vinkel Simon Francis Thomsen Alexandra Avgustinova Salvador Aznar Benitah Paola Lovato Hanne Norsgaard Mette Sidsel Mortensen Lone Veng Björn Rozell Cord Brakebusch Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation |
| description |
Although IL-23 is expressed by psoriatic keratinocytes as well as immune cells, only the immune cell derived IL-23 is thought to be important for the development of psoriasis. Here the authors provide evidence that keratinocyte-produced IL-23 is sufficient to cause a chronic skin inflammation. |
| format |
article |
| author |
Hui Li Qi Yao Alberto Garcia Mariscal Xudong Wu Justus Hülse Esben Pedersen Kristian Helin Ari Waisman Caroline Vinkel Simon Francis Thomsen Alexandra Avgustinova Salvador Aznar Benitah Paola Lovato Hanne Norsgaard Mette Sidsel Mortensen Lone Veng Björn Rozell Cord Brakebusch |
| author_facet |
Hui Li Qi Yao Alberto Garcia Mariscal Xudong Wu Justus Hülse Esben Pedersen Kristian Helin Ari Waisman Caroline Vinkel Simon Francis Thomsen Alexandra Avgustinova Salvador Aznar Benitah Paola Lovato Hanne Norsgaard Mette Sidsel Mortensen Lone Veng Björn Rozell Cord Brakebusch |
| author_sort |
Hui Li |
| title |
Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation |
| title_short |
Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation |
| title_full |
Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation |
| title_fullStr |
Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation |
| title_full_unstemmed |
Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation |
| title_sort |
epigenetic control of il-23 expression in keratinocytes is important for chronic skin inflammation |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/ff608c11582641e39fc4e9d15e15de48 |
| work_keys_str_mv |
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| _version_ |
1718383374433779712 |