Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity

There is interest in developing long-lasting local anaesthetics for a range of applications. Here, the authors report on the application of tetrodotoxin conjugated to amphiphilic biodegradable polymer to reduce systemic toxicity, achieve sustained release and investigate application as a local anaes...

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Autores principales: Chao Zhao, Andong Liu, Claudia M. Santamaria, Andre Shomorony, Tianjiao Ji, Tuo Wei, Akiva Gordon, Hannes Elofsson, Manisha Mehta, Rong Yang, Daniel S. Kohane
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/ffb38a927fed4ae3b9ed75e944b4710c
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