Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity

There is interest in developing long-lasting local anaesthetics for a range of applications. Here, the authors report on the application of tetrodotoxin conjugated to amphiphilic biodegradable polymer to reduce systemic toxicity, achieve sustained release and investigate application as a local anaes...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chao Zhao, Andong Liu, Claudia M. Santamaria, Andre Shomorony, Tianjiao Ji, Tuo Wei, Akiva Gordon, Hannes Elofsson, Manisha Mehta, Rong Yang, Daniel S. Kohane
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ffb38a927fed4ae3b9ed75e944b4710c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ffb38a927fed4ae3b9ed75e944b4710c
record_format	dspace
spelling	oai:doaj.org-article:ffb38a927fed4ae3b9ed75e944b4710c2021-12-02T16:50:59ZPolymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity10.1038/s41467-019-10296-92041-1723https://doaj.org/article/ffb38a927fed4ae3b9ed75e944b4710c2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10296-9https://doaj.org/toc/2041-1723There is interest in developing long-lasting local anaesthetics for a range of applications. Here, the authors report on the application of tetrodotoxin conjugated to amphiphilic biodegradable polymer to reduce systemic toxicity, achieve sustained release and investigate application as a local anaesthetic.Chao ZhaoAndong LiuClaudia M. SantamariaAndre ShomoronyTianjiao JiTuo WeiAkiva GordonHannes ElofssonManisha MehtaRong YangDaniel S. KohaneNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chao Zhao Andong Liu Claudia M. Santamaria Andre Shomorony Tianjiao Ji Tuo Wei Akiva Gordon Hannes Elofsson Manisha Mehta Rong Yang Daniel S. Kohane Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity
description	There is interest in developing long-lasting local anaesthetics for a range of applications. Here, the authors report on the application of tetrodotoxin conjugated to amphiphilic biodegradable polymer to reduce systemic toxicity, achieve sustained release and investigate application as a local anaesthetic.
format	article
author	Chao Zhao Andong Liu Claudia M. Santamaria Andre Shomorony Tianjiao Ji Tuo Wei Akiva Gordon Hannes Elofsson Manisha Mehta Rong Yang Daniel S. Kohane
author_facet	Chao Zhao Andong Liu Claudia M. Santamaria Andre Shomorony Tianjiao Ji Tuo Wei Akiva Gordon Hannes Elofsson Manisha Mehta Rong Yang Daniel S. Kohane
author_sort	Chao Zhao
title	Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity
title_short	Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity
title_full	Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity
title_fullStr	Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity
title_full_unstemmed	Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity
title_sort	polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ffb38a927fed4ae3b9ed75e944b4710c
work_keys_str_mv	AT chaozhao polymertetrodotoxinconjugatestoinduceprolongeddurationlocalanesthesiawithminimaltoxicity AT andongliu polymertetrodotoxinconjugatestoinduceprolongeddurationlocalanesthesiawithminimaltoxicity AT claudiamsantamaria polymertetrodotoxinconjugatestoinduceprolongeddurationlocalanesthesiawithminimaltoxicity AT andreshomorony polymertetrodotoxinconjugatestoinduceprolongeddurationlocalanesthesiawithminimaltoxicity AT tianjiaoji polymertetrodotoxinconjugatestoinduceprolongeddurationlocalanesthesiawithminimaltoxicity AT tuowei polymertetrodotoxinconjugatestoinduceprolongeddurationlocalanesthesiawithminimaltoxicity AT akivagordon polymertetrodotoxinconjugatestoinduceprolongeddurationlocalanesthesiawithminimaltoxicity AT hanneselofsson polymertetrodotoxinconjugatestoinduceprolongeddurationlocalanesthesiawithminimaltoxicity AT manishamehta polymertetrodotoxinconjugatestoinduceprolongeddurationlocalanesthesiawithminimaltoxicity AT rongyang polymertetrodotoxinconjugatestoinduceprolongeddurationlocalanesthesiawithminimaltoxicity AT danielskohane polymertetrodotoxinconjugatestoinduceprolongeddurationlocalanesthesiawithminimaltoxicity
_version_	1718383017097953280

Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity

Ejemplares similares