Increased burden of ultra-rare structural variants localizing to boundaries of topologically associated domains in schizophrenia

Increased burden of ultra-rare structural variants localizing to boundaries of topologically associated domains in schizophrenia

Common variants identified by large-scale genomewide association studies cannot account fully account for the heritability of schizophrenia (SCZ). Here, the authors report high-coverage whole-genome sequencing of 1162 SCZ cases and 936 controls and explore the contribution of different types of vari...

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Autores principales: Matthew Halvorsen, Ruth Huh, Nikolay Oskolkov, Jia Wen, Sergiu Netotea, Paola Giusti-Rodriguez, Robert Karlsson, Julien Bryois, Björn Nystedt, Adam Ameur, Anna K. Kähler, NaEshia Ancalade, Martilias Farrell, James J. Crowley, Yun Li, Patrik K. E. Magnusson, Ulf Gyllensten, Christina M. Hultman, Patrick F. Sullivan, Jin P. Szatkiewicz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/ffbf39facefd4e1c9aa1447004dfe979
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https://doaj.org/article/ffbf39facefd4e1c9aa1447004dfe979

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