Increased burden of ultra-rare structural variants localizing to boundaries of topologically associated domains in schizophrenia

Common variants identified by large-scale genomewide association studies cannot account fully account for the heritability of schizophrenia (SCZ). Here, the authors report high-coverage whole-genome sequencing of 1162 SCZ cases and 936 controls and explore the contribution of different types of vari...

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Autores principales:	Matthew Halvorsen, Ruth Huh, Nikolay Oskolkov, Jia Wen, Sergiu Netotea, Paola Giusti-Rodriguez, Robert Karlsson, Julien Bryois, Björn Nystedt, Adam Ameur, Anna K. Kähler, NaEshia Ancalade, Martilias Farrell, James J. Crowley, Yun Li, Patrik K. E. Magnusson, Ulf Gyllensten, Christina M. Hultman, Patrick F. Sullivan, Jin P. Szatkiewicz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ffbf39facefd4e1c9aa1447004dfe979
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spelling	oai:doaj.org-article:ffbf39facefd4e1c9aa1447004dfe9792021-12-02T14:41:00ZIncreased burden of ultra-rare structural variants localizing to boundaries of topologically associated domains in schizophrenia10.1038/s41467-020-15707-w2041-1723https://doaj.org/article/ffbf39facefd4e1c9aa1447004dfe9792020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15707-whttps://doaj.org/toc/2041-1723Common variants identified by large-scale genomewide association studies cannot account fully account for the heritability of schizophrenia (SCZ). Here, the authors report high-coverage whole-genome sequencing of 1162 SCZ cases and 936 controls and explore the contribution of different types of variants to SCZ.Matthew HalvorsenRuth HuhNikolay OskolkovJia WenSergiu NetoteaPaola Giusti-RodriguezRobert KarlssonJulien BryoisBjörn NystedtAdam AmeurAnna K. KählerNaEshia AncaladeMartilias FarrellJames J. CrowleyYun LiPatrik K. E. MagnussonUlf GyllenstenChristina M. HultmanPatrick F. SullivanJin P. SzatkiewiczNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthew Halvorsen Ruth Huh Nikolay Oskolkov Jia Wen Sergiu Netotea Paola Giusti-Rodriguez Robert Karlsson Julien Bryois Björn Nystedt Adam Ameur Anna K. Kähler NaEshia Ancalade Martilias Farrell James J. Crowley Yun Li Patrik K. E. Magnusson Ulf Gyllensten Christina M. Hultman Patrick F. Sullivan Jin P. Szatkiewicz Increased burden of ultra-rare structural variants localizing to boundaries of topologically associated domains in schizophrenia
description	Common variants identified by large-scale genomewide association studies cannot account fully account for the heritability of schizophrenia (SCZ). Here, the authors report high-coverage whole-genome sequencing of 1162 SCZ cases and 936 controls and explore the contribution of different types of variants to SCZ.
format	article
author	Matthew Halvorsen Ruth Huh Nikolay Oskolkov Jia Wen Sergiu Netotea Paola Giusti-Rodriguez Robert Karlsson Julien Bryois Björn Nystedt Adam Ameur Anna K. Kähler NaEshia Ancalade Martilias Farrell James J. Crowley Yun Li Patrik K. E. Magnusson Ulf Gyllensten Christina M. Hultman Patrick F. Sullivan Jin P. Szatkiewicz
author_facet	Matthew Halvorsen Ruth Huh Nikolay Oskolkov Jia Wen Sergiu Netotea Paola Giusti-Rodriguez Robert Karlsson Julien Bryois Björn Nystedt Adam Ameur Anna K. Kähler NaEshia Ancalade Martilias Farrell James J. Crowley Yun Li Patrik K. E. Magnusson Ulf Gyllensten Christina M. Hultman Patrick F. Sullivan Jin P. Szatkiewicz
author_sort	Matthew Halvorsen
title	Increased burden of ultra-rare structural variants localizing to boundaries of topologically associated domains in schizophrenia
title_short	Increased burden of ultra-rare structural variants localizing to boundaries of topologically associated domains in schizophrenia
title_full	Increased burden of ultra-rare structural variants localizing to boundaries of topologically associated domains in schizophrenia
title_fullStr	Increased burden of ultra-rare structural variants localizing to boundaries of topologically associated domains in schizophrenia
title_full_unstemmed	Increased burden of ultra-rare structural variants localizing to boundaries of topologically associated domains in schizophrenia
title_sort	increased burden of ultra-rare structural variants localizing to boundaries of topologically associated domains in schizophrenia
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ffbf39facefd4e1c9aa1447004dfe979
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Increased burden of ultra-rare structural variants localizing to boundaries of topologically associated domains in schizophrenia

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