Host responses to melioidosis and tuberculosis are both dominated by interferon-mediated signaling.

Melioidosis (Burkholderia pseudomallei infection) is a common cause of community-acquired sepsis in Northeast Thailand and northern Australia. B. pseudomallei is a soil saprophyte endemic to Southeast Asia and northern Australia. The clinical presentation of melioidosis may mimic tuberculosis (both...

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Autores principales:	Gavin C K W Koh, M Fernanda Schreiber, Ruben Bautista, Rapeephan R Maude, Susanna Dunachie, Direk Limmathurotsakul, Nicholas P J Day, Gordon Dougan, Sharon J Peacock
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ffe53b43f87e44d0b91dc40b9f535cd7
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spelling	oai:doaj.org-article:ffe53b43f87e44d0b91dc40b9f535cd72021-11-18T07:59:40ZHost responses to melioidosis and tuberculosis are both dominated by interferon-mediated signaling.1932-620310.1371/journal.pone.0054961https://doaj.org/article/ffe53b43f87e44d0b91dc40b9f535cd72013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23383015/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Melioidosis (Burkholderia pseudomallei infection) is a common cause of community-acquired sepsis in Northeast Thailand and northern Australia. B. pseudomallei is a soil saprophyte endemic to Southeast Asia and northern Australia. The clinical presentation of melioidosis may mimic tuberculosis (both cause chronic suppurative lesions unresponsive to conventional antibiotics and both commonly affect the lungs). The two diseases have overlapping risk profiles (e.g., diabetes, corticosteroid use), and both B. pseudomallei and Mycobacterium tuberculosis are intracellular pathogens. There are however important differences: the majority of melioidosis cases are acute, not chronic, and present with severe sepsis and a mortality rate that approaches 50% despite appropriate antimicrobial therapy. By contrast, tuberculosis is characteristically a chronic illness with mortality <2% with appropriate antimicrobial chemotherapy. We examined the gene expression profiles of total peripheral leukocytes in two cohorts of patients, one with acute melioidosis (30 patients and 30 controls) and another with tuberculosis (20 patients and 24 controls). Interferon-mediated responses dominate the host response to both infections, and both type 1 and type 2 interferon responses are important. An 86-gene signature previously thought to be specific for tuberculosis is also found in melioidosis. We conclude that the host responses to melioidosis and to tuberculosis are similar: both are dominated by interferon-signalling pathways and this similarity means gene expression signatures from whole blood do not distinguish between these two diseases.Gavin C K W KohM Fernanda SchreiberRuben BautistaRapeephan R MaudeSusanna DunachieDirek LimmathurotsakulNicholas P J DayGordon DouganSharon J PeacockPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e54961 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gavin C K W Koh M Fernanda Schreiber Ruben Bautista Rapeephan R Maude Susanna Dunachie Direk Limmathurotsakul Nicholas P J Day Gordon Dougan Sharon J Peacock Host responses to melioidosis and tuberculosis are both dominated by interferon-mediated signaling.
description	Melioidosis (Burkholderia pseudomallei infection) is a common cause of community-acquired sepsis in Northeast Thailand and northern Australia. B. pseudomallei is a soil saprophyte endemic to Southeast Asia and northern Australia. The clinical presentation of melioidosis may mimic tuberculosis (both cause chronic suppurative lesions unresponsive to conventional antibiotics and both commonly affect the lungs). The two diseases have overlapping risk profiles (e.g., diabetes, corticosteroid use), and both B. pseudomallei and Mycobacterium tuberculosis are intracellular pathogens. There are however important differences: the majority of melioidosis cases are acute, not chronic, and present with severe sepsis and a mortality rate that approaches 50% despite appropriate antimicrobial therapy. By contrast, tuberculosis is characteristically a chronic illness with mortality <2% with appropriate antimicrobial chemotherapy. We examined the gene expression profiles of total peripheral leukocytes in two cohorts of patients, one with acute melioidosis (30 patients and 30 controls) and another with tuberculosis (20 patients and 24 controls). Interferon-mediated responses dominate the host response to both infections, and both type 1 and type 2 interferon responses are important. An 86-gene signature previously thought to be specific for tuberculosis is also found in melioidosis. We conclude that the host responses to melioidosis and to tuberculosis are similar: both are dominated by interferon-signalling pathways and this similarity means gene expression signatures from whole blood do not distinguish between these two diseases.
format	article
author	Gavin C K W Koh M Fernanda Schreiber Ruben Bautista Rapeephan R Maude Susanna Dunachie Direk Limmathurotsakul Nicholas P J Day Gordon Dougan Sharon J Peacock
author_facet	Gavin C K W Koh M Fernanda Schreiber Ruben Bautista Rapeephan R Maude Susanna Dunachie Direk Limmathurotsakul Nicholas P J Day Gordon Dougan Sharon J Peacock
author_sort	Gavin C K W Koh
title	Host responses to melioidosis and tuberculosis are both dominated by interferon-mediated signaling.
title_short	Host responses to melioidosis and tuberculosis are both dominated by interferon-mediated signaling.
title_full	Host responses to melioidosis and tuberculosis are both dominated by interferon-mediated signaling.
title_fullStr	Host responses to melioidosis and tuberculosis are both dominated by interferon-mediated signaling.
title_full_unstemmed	Host responses to melioidosis and tuberculosis are both dominated by interferon-mediated signaling.
title_sort	host responses to melioidosis and tuberculosis are both dominated by interferon-mediated signaling.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/ffe53b43f87e44d0b91dc40b9f535cd7
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Host responses to melioidosis and tuberculosis are both dominated by interferon-mediated signaling.

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