Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer

Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer

Glycolysis is elevated in many cancers. In this study, the authors show that lactoylglutathione, a by-product of methylglyoxal produced from increased glycolysis, is elevated in lung cancer in mouse models and humans, arguing reactive metabolite production can be a liability for cancers.

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Bibliographic Details
Main Authors: Alba Luengo, Keene L. Abbott, Shawn M. Davidson, Aaron M. Hosios, Brandon Faubert, Sze Ham Chan, Elizaveta Freinkman, Lauren G. Zacharias, Thomas P. Mathews, Clary B. Clish, Ralph J. DeBerardinis, Caroline A. Lewis, Matthew G. Vander Heiden
Format: article
Language:EN
Published: Nature Portfolio 2019
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Science
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Online Access:https://doaj.org/article/ffedc81cd29a41c396c00462dba0a351
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Internet

https://doaj.org/article/ffedc81cd29a41c396c00462dba0a351

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