Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells

Although IFNγ is a Th1 signature cytokine and is repressed in Th2 cells, it is reactivated in a subset of memory Th2 cells. Here the authors show that Hdac2 is released from Gata3 by Akt-mediated phosphorylation, leading to transcriptional derepression of Tbx21 and IFNγin these cells.

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Autores principales: Hiroyuki Hosokawa, Tomoaki Tanaka, Yusuke Endo, Miki Kato, Kenta Shinoda, Akane Suzuki, Shinichiro Motohashi, Masaki Matsumoto, Keiichi I. Nakayama, Toshinori Nakayama
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/fff71284491b4d75b27b5edb00830b7f
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