Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells

Although IFNγ is a Th1 signature cytokine and is repressed in Th2 cells, it is reactivated in a subset of memory Th2 cells. Here the authors show that Hdac2 is released from Gata3 by Akt-mediated phosphorylation, leading to transcriptional derepression of Tbx21 and IFNγin these cells.

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Autores principales:	Hiroyuki Hosokawa, Tomoaki Tanaka, Yusuke Endo, Miki Kato, Kenta Shinoda, Akane Suzuki, Shinichiro Motohashi, Masaki Matsumoto, Keiichi I. Nakayama, Toshinori Nakayama
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fff71284491b4d75b27b5edb00830b7f
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spelling	oai:doaj.org-article:fff71284491b4d75b27b5edb00830b7f2021-12-02T16:58:12ZAkt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells10.1038/ncomms112892041-1723https://doaj.org/article/fff71284491b4d75b27b5edb00830b7f2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11289https://doaj.org/toc/2041-1723Although IFNγ is a Th1 signature cytokine and is repressed in Th2 cells, it is reactivated in a subset of memory Th2 cells. Here the authors show that Hdac2 is released from Gata3 by Akt-mediated phosphorylation, leading to transcriptional derepression of Tbx21 and IFNγin these cells.Hiroyuki HosokawaTomoaki TanakaYusuke EndoMiki KatoKenta ShinodaAkane SuzukiShinichiro MotohashiMasaki MatsumotoKeiichi I. NakayamaToshinori NakayamaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hiroyuki Hosokawa Tomoaki Tanaka Yusuke Endo Miki Kato Kenta Shinoda Akane Suzuki Shinichiro Motohashi Masaki Matsumoto Keiichi I. Nakayama Toshinori Nakayama Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells
description	Although IFNγ is a Th1 signature cytokine and is repressed in Th2 cells, it is reactivated in a subset of memory Th2 cells. Here the authors show that Hdac2 is released from Gata3 by Akt-mediated phosphorylation, leading to transcriptional derepression of Tbx21 and IFNγin these cells.
format	article
author	Hiroyuki Hosokawa Tomoaki Tanaka Yusuke Endo Miki Kato Kenta Shinoda Akane Suzuki Shinichiro Motohashi Masaki Matsumoto Keiichi I. Nakayama Toshinori Nakayama
author_facet	Hiroyuki Hosokawa Tomoaki Tanaka Yusuke Endo Miki Kato Kenta Shinoda Akane Suzuki Shinichiro Motohashi Masaki Matsumoto Keiichi I. Nakayama Toshinori Nakayama
author_sort	Hiroyuki Hosokawa
title	Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells
title_short	Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells
title_full	Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells
title_fullStr	Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells
title_full_unstemmed	Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells
title_sort	akt1-mediated gata3 phosphorylation controls the repression of ifnγ in memory-type th2 cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/fff71284491b4d75b27b5edb00830b7f
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Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells

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