Enhanced IL-6/IL-6R signaling promotes growth and malignant properties in EBV-infected premalignant and cancerous nasopharyngeal epithelial cells.

Enhanced IL-6/IL-6R signaling promotes growth and malignant properties in EBV-infected premalignant and cancerous nasopharyngeal epithelial cells.

Nasopharyngeal carcinoma (NPC) is etiologically associated with Epstein-Barr virus (EBV) infection. However, the exact role of EBV in NPC pathogenesis remains elusive. Activation of signal transducer and activator of transcription 3 (STAT3) is common in human cancers including NPC and plays an impor...

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Main Authors: Guitao Zhang, Chi Man Tsang, Wen Deng, Yim Ling Yip, Vivian Wai-Yan Lui, Sze Chuen Cesar Wong, Annie Lai-Man Cheung, Pok Man Hau, Musheng Zeng, Maria Li Lung, Honglin Chen, Kwok Wai Lo, Kenzo Takada, Sai Wah Tsao
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/fffdc09df8444f2ca0cf90e6ebca3d8e
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https://doaj.org/article/fffdc09df8444f2ca0cf90e6ebca3d8e

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