Stapled BH3 peptides against MCL-1: mechanism and design using atomistic simulations.

Atomistic simulations of a set of stapled alpha helical peptides derived from the BH3 helix of MCL-1 (Stewart et al. (2010) Nat Chem Biol 6: 595-601) complexed to a fragment (residues 172-320) of MCL-1 revealed that the highest affinity is achieved when the staples engage the surface of MCL-1 as has...

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Autores principales: Thomas L Joseph, David P Lane, Chandra S Verma
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/fffe6b2a38e8478b87a25c55fafbf269
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