Obesidad y ácidos grasos en la etiología de la resistencia insulínica

Fatty acids, obesity and insulin resistance relationship are discussed. In the last decades fatty acids (FA) have been implicated in the etiology of insulin resistance. Initially, this process was related to FA inhibitory effects on glucose uptake mediated by the FA oxidation metabolites. This mecha...

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Autores principales:	Galgani F,José, Díaz B,Erik
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2000
Materias:	Fatty acids Glucose Insuline resistance Obesity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001200008
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spelling	oai:scielo:S0034-988720000012000082001-02-08Obesidad y ácidos grasos en la etiología de la resistencia insulínicaGalgani F,JoséDíaz B,Erik Fatty acids Glucose Insuline resistance Obesity Fatty acids, obesity and insulin resistance relationship are discussed. In the last decades fatty acids (FA) have been implicated in the etiology of insulin resistance. Initially, this process was related to FA inhibitory effects on glucose uptake mediated by the FA oxidation metabolites. This mechanism known as the Randle cycle has been presently discarded based on recent evidence for FA effects on glucose metabolism. Now is known that cytosolic lipid content and FA molecular structure determines higher or lower storage and oxidation capacity. Another factor is given by Tumor Necrosis Factor-a, which is overexpressed in animal and human obesity, producing insulin signaling and glucose uptake inhibition. This paper discuss the role played by FA and obesity on insulin resistance, mainly in relation to FA effects on glucose metabolism in the liver, muscle and adipose tissues. In the obesity condition adipose tissue releases higher levels of free FA which in turn stimulates hepatic glucose production. Adipose tissue also, increase TNF-a secretion impairing glucose utilization and insulin signaling. In muscle, cytosolic lipid content activate a Protein Kinase that inhibits the insulin signaling and reduce GLUT-4 translocation. The study of cellular and metabolic changes associated to weight gain and its relationship with insulin resistance etiology are encouraged (Rev Méd Chile 2000; 128: 1354-60).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.128 n.12 20002000-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001200008es10.4067/S0034-98872000001200008
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Fatty acids Glucose Insuline resistance Obesity
spellingShingle	Fatty acids Glucose Insuline resistance Obesity Galgani F,José Díaz B,Erik Obesidad y ácidos grasos en la etiología de la resistencia insulínica
description	Fatty acids, obesity and insulin resistance relationship are discussed. In the last decades fatty acids (FA) have been implicated in the etiology of insulin resistance. Initially, this process was related to FA inhibitory effects on glucose uptake mediated by the FA oxidation metabolites. This mechanism known as the Randle cycle has been presently discarded based on recent evidence for FA effects on glucose metabolism. Now is known that cytosolic lipid content and FA molecular structure determines higher or lower storage and oxidation capacity. Another factor is given by Tumor Necrosis Factor-a, which is overexpressed in animal and human obesity, producing insulin signaling and glucose uptake inhibition. This paper discuss the role played by FA and obesity on insulin resistance, mainly in relation to FA effects on glucose metabolism in the liver, muscle and adipose tissues. In the obesity condition adipose tissue releases higher levels of free FA which in turn stimulates hepatic glucose production. Adipose tissue also, increase TNF-a secretion impairing glucose utilization and insulin signaling. In muscle, cytosolic lipid content activate a Protein Kinase that inhibits the insulin signaling and reduce GLUT-4 translocation. The study of cellular and metabolic changes associated to weight gain and its relationship with insulin resistance etiology are encouraged (Rev Méd Chile 2000; 128: 1354-60).
author	Galgani F,José Díaz B,Erik
author_facet	Galgani F,José Díaz B,Erik
author_sort	Galgani F,José
title	Obesidad y ácidos grasos en la etiología de la resistencia insulínica
title_short	Obesidad y ácidos grasos en la etiología de la resistencia insulínica
title_full	Obesidad y ácidos grasos en la etiología de la resistencia insulínica
title_fullStr	Obesidad y ácidos grasos en la etiología de la resistencia insulínica
title_full_unstemmed	Obesidad y ácidos grasos en la etiología de la resistencia insulínica
title_sort	obesidad y ácidos grasos en la etiología de la resistencia insulínica
publisher	Sociedad Médica de Santiago
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001200008
work_keys_str_mv	AT galganifjose obesidadyacidosgrasosenlaetiologiadelaresistenciainsulinica AT diazberik obesidadyacidosgrasosenlaetiologiadelaresistenciainsulinica
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Obesidad y ácidos grasos en la etiología de la resistencia insulínica

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